Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease

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Abstract

We have previously shown that PACAP ameliorates the neurological symptoms and reduces the dopaminergic cell loss in young male rats, in a 6-hydroxydopamine (6-OHDA)-induced lesion of the substantia nigra, a model of Parkinson's disease. In the present study, we compared the effects of PACAP in young, aging, and castrated males. Our results show that PACAP significantly reduced the dopaminergic cell loss in young and aging males. In castrated males, 6-OHDA did not induce such a severe cell loss, and it was not altered by PACAP. However, PACAP effectively ameliorated behavioral symptoms in all groups, with a degree of recovery depending on age and endocrine status.

Original languageEnglish
Pages (from-to)518-524
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1070
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Age
  • Gender
  • Neuroprotection
  • PACAP
  • Parkinson

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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