Comparative study of the antidiuretic effects of adiuretin-SD (DDAVP) and Pitressin Tannate in diabetes insipidus

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Abstract

An account is given of experience acquired with the prolonged administration of a new vasopressin analogue, 1-deamino-8-D-arginine vasopressin (DDAVP), to patients with diabetes insipidus. The antidiuretic effect of this compound was compared with that of the long-acting Pitressin Tannate, containing a pituitary extract. It was found that DDAVP induces a far more significant antidiuretic effect than does Pitressin Tannate. Its application is not accompanied by any side effects, nor is its effectiveness decreased after repeated administration. Similar conclusions were reached with the outpatient treatment of diabetes insipidus patients. The results indicate that nasally-administered Adiuretin-SD can be well utilized in the prolonged treatment of diabetes insipidus.

Original languageEnglish
Pages (from-to)10-13
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume16
Issue number1
Publication statusPublished - 1978

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Antidiuretic Agents
Deamino Arginine Vasopressin
Diabetes Insipidus
Medical problems
Vasopressins
Outpatients
Therapeutics
pitressin tannate

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

Cite this

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abstract = "An account is given of experience acquired with the prolonged administration of a new vasopressin analogue, 1-deamino-8-D-arginine vasopressin (DDAVP), to patients with diabetes insipidus. The antidiuretic effect of this compound was compared with that of the long-acting Pitressin Tannate, containing a pituitary extract. It was found that DDAVP induces a far more significant antidiuretic effect than does Pitressin Tannate. Its application is not accompanied by any side effects, nor is its effectiveness decreased after repeated administration. Similar conclusions were reached with the outpatient treatment of diabetes insipidus patients. The results indicate that nasally-administered Adiuretin-SD can be well utilized in the prolonged treatment of diabetes insipidus.",
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