Comparative study of platelet 3H-paroxetine and 3H-imipramine binding in panic disorder patients and healthy controls

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Abstract

High affinity 3H-paroxetine and 3H-imipramine binding sites were simultaneously studied in platelets of 29 untreated patients with panic disorder and 12 healthy controls. The maximum number of binding sites (B(max)) was found to be significantly lower in the panic patients compared to the controls using either ligand. No difference in the K(d) values between the groups of subjects was found. The disturbance of serotonin neurotransmission in panic disorder - decrease in B(max) values - may be either a consequence or a reason of serotonergic dysfunction.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalJournal of Psychiatry and Neuroscience
Volume19
Issue number2
Publication statusPublished - May 3 1994

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Keywords

  • binding
  • imipramine
  • panic disorder
  • paroxetine
  • platelet
  • serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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