Vergleichende Untersuchungen über den Gehalt des Plasmas an lysosomalen und cytoplasmatischen Enzymen, Milchsäure und Brenztraubensäure während des hämorrhagischen Schocks bei Hunden

Translated title of the contribution: Comparative study of plasma levels of cytoplasmic and lysosomal enzymes and that of lactate and pyruvate in haemorrhagic shock of the dog

G. Horpácsy, T. Barankay, K. Tárnoky, S. Nagy, G. Petri

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Plasma levels of lactate pyruvate, "excess lactate", lactat-dehydrogenase (LDH), leucin-aminopeptidase (LAP) as well as lysosomal acid phosphatase and beta-glucuronidase have been investigated in haemorrhagic shock. It was found that the increase of anaerobic metabolites and LDH indicated promptly the presence of tissue hypoxia in the initial stage of shock. The increase of activity of lysosomal enzymes occoured only in the more severe stage of shock. After reinfusion of the shed blood the plasma levels of LDH increased markedly while that of LAP and acid phosphatase increased moderately, lactate and "excess lactate" remained unaltered. The plasma levels of the enzymes and metabolites studied in these experiments except LDH decreased 90 min after reinfusion. These result indicate that the accumulation of enzymes and anaerobic metabolites may be characteristic to the severity of haemorrhagic shock.

Original languageGerman
Pages (from-to)274-282
Number of pages9
JournalZeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie
Volume154
Issue number4
DOIs
Publication statusPublished - Apr 1 1971

    Fingerprint

Keywords

  • Anaerobic metabolites
  • Haemorrhagic shock
  • LAP
  • LDH
  • Lysosomal enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this