Comparative study of nanosized cross-linked sodium-, linear sodium- and zinc-hyaluronate as potential ocular mucoadhesive drug delivery systems

Gabriella Horvát, Mária Budai-Szucs, Szilvia Berkó, Piroska Szabó-Révész, Judit Soós, Andrea Facskó, Mónika Maroda, Michela Mori, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Erzsébet Csányi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Hyaluronic acid (HA) and its derivatives play important roles in many fields of therapy, such as arthritis treatment, plastic surgery, dermatology, otology, ophthalmology, etc. With a view to increase the beneficial properties of HA in ocular drug delivery, many types of chemical structural modifications have been performed. In the course of our research work, we characterized nanosized cross-linked - (CLNaHA), linear sodium hyaluronate (NaHA) and zinc-hyaluronate (ZnHA), as potential ocular drug delivery systems. The aim was to determine the influence of the structure on biocompatibility, mucoadhesion and drug release. The structure was characterized by means of rheology. The cytotoxicity of the samples was determined on rabbit corneal epithelial cells (RCE) by the MTT test. Mucoadhesion measurements were made by a rheological method in vitro and by tensile tests in vitro and ex vivo. The release of sodium diclofenac, a frequently used non-steroidal anti-inflammatory drug with low bioavailability, from the gels was determined with a vertical Franz diffusion cell. The results demonstrated that all three derivatives have adequate mucoadhesive properties and their rapid drug release profiles are beneficial in ocular therapy. Thanks to these properties, the bioavailability of the ophthalmic preparations can be increased, especially with the application of CLNaHA.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume494
Issue number1
DOIs
Publication statusPublished - Oct 15 2015

    Fingerprint

Keywords

  • Cross-linked sodium hyaluronate
  • Cytotoxicity
  • Hyaluronic acid
  • Mucoadhesion
  • Ocular drug release
  • Zinc hyaluronate

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Horvát, G., Budai-Szucs, M., Berkó, S., Szabó-Révész, P., Soós, J., Facskó, A., Maroda, M., Mori, M., Sandri, G., Bonferoni, M. C., Caramella, C., & Csányi, E. (2015). Comparative study of nanosized cross-linked sodium-, linear sodium- and zinc-hyaluronate as potential ocular mucoadhesive drug delivery systems. International Journal of Pharmaceutics, 494(1), 321-328. https://doi.org/10.1016/j.ijpharm.2015.08.024