Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide

V. Kecskeméti, Pal Pacher, Csaba Pankucsi, P. Nánási

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effects of atrial natriuretic peptide (ANP) on action potential characteristics were studied in various (human, rabbit, guinea-pig) atrial and guinea-pig right ventricular papillary muscles. ANP (1-100 nM) did not modify the resting membrane potential nor the maximum rate of depolarization phase (V(max)). Up to 10 nM, ANP dose-dependently decreased the action potential amplitude both in guinea-pig atrial and ventricular muscles, but it did not affect this parameter in the other atrial preparations. ANP caused a dose-dependent, marked decrease of action potential duration (APD) in practically every cardiac preparation studied (exception of guinea-pig left atrium). The strongest effect on APD can be observed in human atrial and guinea-pig ventricular fibers. The K+ channel blocker 4-aminopyridine (1 mM) and the ATP-dependent K+ channel inhibitor glibenclamide (10 μM) prevented the effect of ANP on APD in both ventricular atrial preparations. ANP prevented the appearance of isoprenaline (0.5 μM) induced slow AP in K+ depolarized myocardium. The present data suggest that ANP may inhibit the slow inward Ca2+ channel activity and facilitate the K+ channel activity.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume160-161
DOIs
Publication statusPublished - 1996

Fingerprint

Atrial Natriuretic Factor
Action Potentials
Guinea Pigs
Muscle
4-Aminopyridine
Papillary Muscles
Glyburide
Depolarization
Heart Atria
Isoproterenol
Membrane Potentials
Myocardium
Adenosine Triphosphate
Rabbits
Membranes
Muscles
Fibers

Keywords

  • Atrial natriuretic peptide
  • Cardiac action potential
  • Glibenclamide
  • Human atrial muscle

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide. / Kecskeméti, V.; Pacher, Pal; Pankucsi, Csaba; Nánási, P.

In: Molecular and Cellular Biochemistry, Vol. 160-161, 1996, p. 53-59.

Research output: Contribution to journalArticle

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