The aim of this study is to prepare bulk calcium silicate system that exhibits suitable properties to be used for biomedical applications. Glass-ceramics of composition CaO·SiO2 were produced by sol-gel technique starting from tetraethoxysilane and calcium nitrate tetrahydrate and by melt-quenching technique using a mixture of CaCO3 and SiO2. The traditional power technology requires 1500°C temperature to produce ceramic bulks; contrarily the sol-gel technique 700°C. Their structures were compared by means of thermoanalysis, X-ray diffraction, and small angle X-ray scattering. In the melt-quenched samples, the crystalline feature is dominated; the gel-derived samples are rather amorphous. The mechanical property of the calcium silicate materials obtained by different preparation routes were characterized by Brinell hardness test. The melt-quenching technology provides the glass-ceramics product with high mechanical strength at 1500°C; the gel derived products achieve this mechanical strength already after a heat treatment at 700°C. The gel derived product prepared with ammonia catalyst proved to be the hardest, most compact matter.