Comparative study of antibodies that are associated with disease progression in HIV disease

F. Tóth, Caner Süsal, E. Újhelyi, D. Bánhegyi, Jolán Kiss, Volker Daniel, Imre Nagy, Gerhard Opelz, G. Füst

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two types of antibodies which previously were found to be inversely associated with CD4+ cell counts and which may contribute to the progression of HIV disease were measured in parallel in 55 serum samples of 7 longitudinally tested HIV-infected patients (4 homosexual men, 3 haemophilic men) and in 15 serum samples from 15 patients with advanced AIDS. HIV-infection enhancing antibodies were determined in the presence of near-physiologic human complement concentration using a complement receptor type 2 (CR2) carrying HIV-target cell line. IgG and IgA class autoantibodies directed against human IgG-Fab fragments were measured in specific ELISA assays. In agreement with our previous studies obtained in HIV-seropositive haemophilic patients, significant negative correlations were found between CD4+ cell counts and IgG anti-Fab and IgA anti-Fab antibodies (Spearman correlation coefficient r=-0.587, P

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalImmunology Letters
Volume41
Issue number1
DOIs
Publication statusPublished - Jun 2 1994

Fingerprint

Disease Progression
HIV
Antibodies
CD4 Lymphocyte Count
CD4 Immunoadhesins
Immunoglobulin G
Complement 3d Receptors
Immunoglobulin Fab Fragments
Blocking Antibodies
Serum
Autoantibodies
Immunoglobulin A
HIV Infections
Anti-Idiotypic Antibodies
Acquired Immunodeficiency Syndrome
Enzyme-Linked Immunosorbent Assay
Cell Line

Keywords

  • AIDS
  • Anti-IgG-Fab autoantibody
  • Autoimmunity
  • Enhancing antibody
  • HIV infection

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Comparative study of antibodies that are associated with disease progression in HIV disease. / Tóth, F.; Süsal, Caner; Újhelyi, E.; Bánhegyi, D.; Kiss, Jolán; Daniel, Volker; Nagy, Imre; Opelz, Gerhard; Füst, G.

In: Immunology Letters, Vol. 41, No. 1, 02.06.1994, p. 33-36.

Research output: Contribution to journalArticle

Tóth, F. ; Süsal, Caner ; Újhelyi, E. ; Bánhegyi, D. ; Kiss, Jolán ; Daniel, Volker ; Nagy, Imre ; Opelz, Gerhard ; Füst, G. / Comparative study of antibodies that are associated with disease progression in HIV disease. In: Immunology Letters. 1994 ; Vol. 41, No. 1. pp. 33-36.
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