Comparative study of β-tricalcium phosphate mixed with platelet-rich plasma versus β-tricalcium phosphate, a bone substitute material in dentistry

Katalin Kovács, N. Velich, T. Huszár, G. Szabó, G. Semjén, J. Reiczigel, Z. Suba

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Animal experiments were carried out with osteoconductive bone substitute β-tricalcium phosphate (β-TCP), with the aim of assessing the effects of the growth factors synthesised by thrombocytes on the speed of β-TCP incorporation and on the quality of newly formed bone. The question to be answered was the extent to which platelet-rich plasma (PRP) accelerated the resorption of β-TCP and the formation of new bone. Two teeth were removed symmetrically from each side of the mandible of 12 Beagle dogs; the resulting cavities were filled on one side with β-TCP alone, and on the other side with a mixture of β-TCP + PRP (obtained from autologous blood). The quality of the newly formed bone and the effects of this PRP were studied by histological and histomorphometric methods. In week 6, bone formation was already more effective when PRP was applied in comparison with β-TCP alone, and in week 12 the growth was significantly greater. The results demonstrate that the use of PRP accelerates the remodelling of new bone created by β-TCP.

Original languageEnglish
Pages (from-to)475-484
Number of pages10
JournalActa Veterinaria Hungarica
Volume51
Issue number4
DOIs
Publication statusPublished - 2003

Fingerprint

tricalcium phosphate
dentistry
Bone Substitutes
Platelet-Rich Plasma
Dentistry
bones
Osteogenesis
blood platelets
mandible (bone)
animal experimentation
resorption
Bone and Bones
bone formation
Beagle
growth factors
Bone Remodeling
teeth
Mandible
Intercellular Signaling Peptides and Proteins
Tooth

Keywords

  • β-tricalcium phosphate
  • Bone substitution
  • Histomorphometry
  • Platelet-rich plasma
  • Remodelling

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparative study of β-tricalcium phosphate mixed with platelet-rich plasma versus β-tricalcium phosphate, a bone substitute material in dentistry. / Kovács, Katalin; Velich, N.; Huszár, T.; Szabó, G.; Semjén, G.; Reiczigel, J.; Suba, Z.

In: Acta Veterinaria Hungarica, Vol. 51, No. 4, 2003, p. 475-484.

Research output: Contribution to journalArticle

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