Comparative studies with somatostatin and cysteamine in different behavioral tests on rats

L. Vécsei, C. Kiraly, I. Bollok, A. Nagy, J. Varga, B. Penke, G. Telegdy

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Abstract

In the present study the effects of somatostatin and cysteamine (a selective decreaser of the somatostatin level in the body) were compared in different behavioral tests on rats. Somatostatin inhibited the extinction of active avoidance behavior 8 hr and 24 hr after intracerebroventricular (ICV) treatment, while cysteamine facilitated it 4 hr and 8 hr after subcutaneous (SC) treatment. Somatostatin did not significantly influence the cysteamine-induced facilitation of the extinction. Somatostatin did not have a significant effect on T-maze spatial discrimination learning and reverse learning, whereas cysteamine markedly attenuated the performance 4 hr (1st day) after treatment. Somatostatin in a dose of 4 μg (ICV) increased the locomotor activity 10 min after treatment, while cysteamine markedly decreased all parameters of the open-field test. These effects of the drug had disappeared 24 hr after treatment. If different doses of somatostatin (4 μg or 10 μg ICV) were administered to cysteamine-pretreated rats, the peptide did not modify the drug-induced changes in the open-field test. The data suggest that the brain somatostatin might have a physiological role in the organization of certain types of behavior.

Original languageEnglish
Pages (from-to)833-837
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume21
Issue number6
DOIs
Publication statusPublished - 1984

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Cysteamine
Somatostatin
Rats
Maze Learning
Avoidance Learning
Discrimination Learning
Behavior Rating Scale
Locomotion
Pharmaceutical Preparations
Brain
Learning
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Comparative studies with somatostatin and cysteamine in different behavioral tests on rats. / Vécsei, L.; Kiraly, C.; Bollok, I.; Nagy, A.; Varga, J.; Penke, B.; Telegdy, G.

In: Pharmacology, Biochemistry and Behavior, Vol. 21, No. 6, 1984, p. 833-837.

Research output: Contribution to journalArticle

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