Comparative studies on retroviral proteases

Substrate specificity

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Exogenous retroviruses are sub classified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1 protease are widely used in AIDS therapy. Resistant mutations occur in response to the drug therapy introducing residues that are frequently found in the equivalent position of other retroviral proteases. Therefore, besides helping to understand the general and specific features of these enzymes, comparative studies of retroviral proteases may help to understand the mutational capacity of the HIV-1 protease.

Original languageEnglish
Pages (from-to)147-165
Number of pages19
JournalViruses
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Substrate Specificity
Peptide Hydrolases
pol Gene Products
Virus Diseases
Retroviridae
Acquired Immunodeficiency Syndrome
Drug Therapy
Mutation
Enzymes
Human immunodeficiency virus 1 p16 protease
Therapeutics

Keywords

  • HIV protease
  • Retroviral proteases
  • Substrate specificity

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Comparative studies on retroviral proteases : Substrate specificity. / Tőzsér, J.

In: Viruses, Vol. 2, No. 1, 01.2010, p. 147-165.

Research output: Contribution to journalArticle

@article{05ce21a2cf274a939524492407cc6c22,
title = "Comparative studies on retroviral proteases: Substrate specificity",
abstract = "Exogenous retroviruses are sub classified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1 protease are widely used in AIDS therapy. Resistant mutations occur in response to the drug therapy introducing residues that are frequently found in the equivalent position of other retroviral proteases. Therefore, besides helping to understand the general and specific features of these enzymes, comparative studies of retroviral proteases may help to understand the mutational capacity of the HIV-1 protease.",
keywords = "HIV protease, Retroviral proteases, Substrate specificity",
author = "J. Tőzs{\'e}r",
year = "2010",
month = "1",
doi = "10.3390/v2010147",
language = "English",
volume = "2",
pages = "147--165",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

TY - JOUR

T1 - Comparative studies on retroviral proteases

T2 - Substrate specificity

AU - Tőzsér, J.

PY - 2010/1

Y1 - 2010/1

N2 - Exogenous retroviruses are sub classified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1 protease are widely used in AIDS therapy. Resistant mutations occur in response to the drug therapy introducing residues that are frequently found in the equivalent position of other retroviral proteases. Therefore, besides helping to understand the general and specific features of these enzymes, comparative studies of retroviral proteases may help to understand the mutational capacity of the HIV-1 protease.

AB - Exogenous retroviruses are sub classified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1 protease are widely used in AIDS therapy. Resistant mutations occur in response to the drug therapy introducing residues that are frequently found in the equivalent position of other retroviral proteases. Therefore, besides helping to understand the general and specific features of these enzymes, comparative studies of retroviral proteases may help to understand the mutational capacity of the HIV-1 protease.

KW - HIV protease

KW - Retroviral proteases

KW - Substrate specificity

UR - http://www.scopus.com/inward/record.url?scp=79952089811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952089811&partnerID=8YFLogxK

U2 - 10.3390/v2010147

DO - 10.3390/v2010147

M3 - Article

VL - 2

SP - 147

EP - 165

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 1

ER -