Comparative studies on retroviral proteases: Substrate specificity

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Exogenous retroviruses are sub classified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1 protease are widely used in AIDS therapy. Resistant mutations occur in response to the drug therapy introducing residues that are frequently found in the equivalent position of other retroviral proteases. Therefore, besides helping to understand the general and specific features of these enzymes, comparative studies of retroviral proteases may help to understand the mutational capacity of the HIV-1 protease.

Original languageEnglish
Pages (from-to)147-165
Number of pages19
JournalViruses
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

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Keywords

  • HIV protease
  • Retroviral proteases
  • Substrate specificity

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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