Comparative studies on genotoxic and carcinogenic effects of different cytostatic protocols. I. In vivo cytogenetic analyses in CBA mice

Cs Varga, I. Ember, T. Raposa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In vivo rodent cytogenetics may provide an important basis for an animal model for the assessment of the carcinogenic potential of antitumor drugs in man. In this paper, genotoxic alterations (i.e. sister chromatid exchanges and micronuclei) caused by different cytostatic protocols in CBA Ca mice are described. The strongest sister chromatid exchange inducing effects were shown by the ABVD (doxorubicin-dacarbazine-bleomycin-vinblastine) group and combinations containing cyclophosphamide. Compounds which affect the mitotic spindle induced only micronuclei, but not sister chromatid exchanges.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalCancer Letters
Volume60
Issue number3
DOIs
Publication statusPublished - Dec 1 1991

Fingerprint

Inbred CBA Mouse
Sister Chromatid Exchange
Cytogenetic Analysis
Cytostatic Agents
Dacarbazine
Spindle Apparatus
Vinblastine
Bleomycin
Cytogenetics
Antineoplastic Agents
Doxorubicin
Cyclophosphamide
Rodentia
Animal Models

Keywords

  • CBA Ca mice
  • cytostatic protocols
  • genotoxicity
  • micronuclei
  • sister chromatid exchanges (SCE)

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Comparative studies on genotoxic and carcinogenic effects of different cytostatic protocols. I. In vivo cytogenetic analyses in CBA mice. / Varga, Cs; Ember, I.; Raposa, T.

In: Cancer Letters, Vol. 60, No. 3, 01.12.1991, p. 199-203.

Research output: Contribution to journalArticle

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