Csontveloi hemopoietikus sejtek összehasonlító vizsgálata hisztamin 4 receptor (H4R) génkiütött és vad genotípusú egerekben

Translated title of the contribution: Comparative studies on bone marrow derived hematopoietic cells of histamine receptor 4 (H4R) knockoout and control mice

E. Pállinger, Horváth Zsuzsanna, A. Falus

Research output: Contribution to journalArticle

Abstract

Besides hemopoietic growth factors, chemokines and cytokines, low molecular weight molecules, such as histamine (H) play relevant role in hematopoiesis. The outcome of the histamine effect depends on the type and density of histamine receptors on target cells. Both H1, H2 and H4 receptors (R) were detected on hematopoietic cells. In our system bone marrow cell populations were studied in genetically modified, H4R gene targeted (H4R-KO) mice by flow cytometry and compared to control animals matched in genetic background, age and sex. The results suggest a significant increase of CD3+/CD4+ Th cell (p=0.04), decrease in ratio of TCR+ T cells p=0.001) subpopulations of H4R deficient mice. Moreover, a significant decrease in CD117+ mast cells (p=0.003) and CD11b+ myeloid cells (p=0.03) was found in H4R-KO animals. These data suggest the considerable regulatory role of local histamine acting through H4 receptor on hematopoietic cell differentiation of bone marrow.

Original languageHungarian
Pages (from-to)121-125
Number of pages5
JournalOrvoskepzes
Volume81
Issue number2
Publication statusPublished - 2006

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Histamine Receptors
Bone Marrow
Histamine
Histamine Agents
Histamine H2 Receptors
Hematopoiesis
Myeloid Cells
Chemokines
Mast Cells
Bone Marrow Cells
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Flow Cytometry
Molecular Weight
Cytokines
T-Lymphocytes
Population
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Csontveloi hemopoietikus sejtek összehasonlító vizsgálata hisztamin 4 receptor (H4R) génkiütött és vad genotípusú egerekben. / Pállinger, E.; Zsuzsanna, Horváth; Falus, A.

In: Orvoskepzes, Vol. 81, No. 2, 2006, p. 121-125.

Research output: Contribution to journalArticle

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