Comparative pharmacokinetic pilot study of two buspirone preparations by gas chromatography-mass spectrometry in dogs

J. Visy, G. Mady, G. Czira, J. Tamas, I. Klebovich, M. Abermann, M. Porcs-Makkay, M. Simonyi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A comparative preliminary pharmacokinetic study of two buspirone preparations, Buspar and Spitomin, was performed after a single 10-mg oral dose as a pilot study in beagle dogs. The buspirone levels of blood sample series taken at 13 different times were determined by gas chromatography-mass spectrometry. For the bioanalytical analysis a new type of tetradeuterated buspirone was synthesized as an internal standard. The pharmacokinetic analysis of the concentration-time curves was carried out by the two-compartment open model. Good agreement of the all pharmacokinetic parameters obtained strongly suggests the pharmacokinetic equivalence of the two preparations.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalPharmaceutical Sciences
Volume3
Issue number4
Publication statusPublished - 1997

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Buspirone
Gas Chromatography-Mass Spectrometry
Pharmacokinetics
Dogs

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Comparative pharmacokinetic pilot study of two buspirone preparations by gas chromatography-mass spectrometry in dogs. / Visy, J.; Mady, G.; Czira, G.; Tamas, J.; Klebovich, I.; Abermann, M.; Porcs-Makkay, M.; Simonyi, M.

In: Pharmaceutical Sciences, Vol. 3, No. 4, 1997, p. 193-196.

Research output: Contribution to journalArticle

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AU - Abermann, M.

AU - Porcs-Makkay, M.

AU - Simonyi, M.

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