Comparative neurochemical investigation of tardive dyskinesia and neuroleptic-induced chronic parkinsonism

Mihály Arató, György Bagdy, András Perényi, Árpád Béla

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Abstract

Cerebrospinal fluid (CSF) homovanillic acid (HVA), cyclic adenosine 3', 5'-monophosphate (cAMP), and serum prolactin were measured in schizophrenic male patients with tardive dyskinesia (TD) and in those exhibiting the symptoms of chronic neuroleptic parkinsonism (P). The patients (nine TD and eight P) were chronic paranoid schizophrenics. Levels of HVA in CSF were found to be significantly higher in the TD group. Normal prolactin levels were observed in both groups and are indicative of tolerance developed in the hypothalamic tuberoinfundibular dopaminergic system.

Original languageEnglish
Pages (from-to)347-351
Number of pages5
JournalPsychiatry research
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 1984

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Keywords

  • Tardive dyskinesia
  • cerebrospinal fluid
  • homovanillic acid
  • serum prolactin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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