Comparative metabolic effects of oral contraceptive preparations containing different progestagens. Effects of desogestrel + ethinylestradiol on the haemostatic balance

I. Rakoczi, Gy Gero, J. Demeter, I. Gati

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Abstract

In two open randomized studies carried out in female volunteers the effects of a new low dose oral contraceptive (O.C.) combination desogestrel + ethinylestradiol (150 μg/30 μg; Marvelon®) on blood coagulation were compared with those of either the combination levonorgestrel + ethinylestradiol (150 μg/30 μg) or a triphasic preparation containing levonorgestrel + ethinylestradiol. A total of 78 women were involved in the studies which covered a period of 4 cycles; a pretreatment cycle followed by 3 treatment cycles, each consisting of 21 days of drug administration, followed by a 7-day tablet-free period. A blood sample was taken before treatment, after 2 weeks, 2 cycles and 3 cycles of treatment. The following parameters were measured: prothrombin; activated partial thromboplastin time; factors VII, VIII, X; fibrinogen; antithrombin III; euglobulin lysis time; platelet count and aggregation ratio; triglycerides and cholesterol; and a glucose tolerance test was made. The effects of the different preparations on these parameters were compared statistically using either an analysis of covariance or the Wilcoxon test. No clinically significant differences were observed between the desogestrel containing preparation and the two other preparations. Any changes in treatment versus pretreatment values were slight and in agreement with the literature on other O.C.'s.

Original languageEnglish
Pages (from-to)630-633
Number of pages4
JournalArzneimittel-Forschung
Volume35
Issue number3
Publication statusPublished - 1985

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Desogestrel
Ethinyl Estradiol
Hemostatics
Progestins
Oral Contraceptives
Levonorgestrel
Blood
Serum Globulins
Factor VII
Antithrombin III
Fibrin Clot Lysis Time
Thromboplastin
Prothrombin
Platelets
Coagulation
Fibrinogen
Tablets
Partial Thromboplastin Time
Factor VIII
Triglycerides

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine(all)

Cite this

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title = "Comparative metabolic effects of oral contraceptive preparations containing different progestagens. Effects of desogestrel + ethinylestradiol on the haemostatic balance",
abstract = "In two open randomized studies carried out in female volunteers the effects of a new low dose oral contraceptive (O.C.) combination desogestrel + ethinylestradiol (150 μg/30 μg; Marvelon{\circledR}) on blood coagulation were compared with those of either the combination levonorgestrel + ethinylestradiol (150 μg/30 μg) or a triphasic preparation containing levonorgestrel + ethinylestradiol. A total of 78 women were involved in the studies which covered a period of 4 cycles; a pretreatment cycle followed by 3 treatment cycles, each consisting of 21 days of drug administration, followed by a 7-day tablet-free period. A blood sample was taken before treatment, after 2 weeks, 2 cycles and 3 cycles of treatment. The following parameters were measured: prothrombin; activated partial thromboplastin time; factors VII, VIII, X; fibrinogen; antithrombin III; euglobulin lysis time; platelet count and aggregation ratio; triglycerides and cholesterol; and a glucose tolerance test was made. The effects of the different preparations on these parameters were compared statistically using either an analysis of covariance or the Wilcoxon test. No clinically significant differences were observed between the desogestrel containing preparation and the two other preparations. Any changes in treatment versus pretreatment values were slight and in agreement with the literature on other O.C.'s.",
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AU - Rakoczi, I.

AU - Gero, Gy

AU - Demeter, J.

AU - Gati, I.

PY - 1985

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