Comparative investigation of antipyrine half-life and induction of cytochrome P-450 dependent monooxygenase in rats treated with phenylurea herbicides

B. Schoket, Z. Zilahy, J. Molnar, I. Vincze

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The short-term effect of three substituted phenylurea herbicides has been investigated on antipyrine plasma half-life in rats. Isoproturon was ineffective, while chlortoluron and diuron decreased the half-life significantly. There was a close correlation between antipyrine half-lives and induction of hepatic cytochrome P-450 dependent benzo (a) pyrene monooxygenase, 7-ethoxycoumarin O-deethylase and 7-ethoxyresorufin O-deethylase.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalIn Vivo
Volume1
Issue number3
Publication statusPublished - 1987

Fingerprint

Antipyrine
Herbicides
Cytochrome P-450 Enzyme System
Half-Life
Rats
Benzopyrene Hydroxylase
7-Alkoxycoumarin O-Dealkylase
Diuron
Cytochrome P-450 CYP1A1
Plasmas
Liver
isoproturon
chlortoluron

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparative investigation of antipyrine half-life and induction of cytochrome P-450 dependent monooxygenase in rats treated with phenylurea herbicides. / Schoket, B.; Zilahy, Z.; Molnar, J.; Vincze, I.

In: In Vivo, Vol. 1, No. 3, 1987, p. 185-188.

Research output: Contribution to journalArticle

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