Comparative immunological studies in ITP

T. Burger, A. Pár, M. Schmelczer

Research output: Contribution to journalArticle

Abstract

Twelve splenectomized and 16 non-splenectomized patients with idiopathic thrombocytopenic purpura (ITP) were studied for autoimmune complement fixation (AICF), indirect immunofluorescence (IF), platelet 'immuno-injury' (T-3), antinuclear antibody (ANA), and serum electrophoresis. AICF was found positive in 50%, IF in 81%, T-3 in 50%, ANA in 69% of splenectomized cases. No significant difference in any of above parameters or in the gamma globulin levels was found between the splenectomized and the non-splenectomized groups. These observations are less favourable than those reported by other workers in post-splenectomy cases of ITP. The results, in agreement with those of earlier lymphocyte-transformation studies of the authors, are consistent with the primary mechanical role of the spleen in ITP, and make it justified to connect the failure of ITP to respond adequately to splenectomy, and the persistent seropositivity in these cases, with an excessive IgG production by the bone marrow.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalActa Medica Academiae Scientiarum Hungaricae
Volume35
Issue number2
Publication statusPublished - 1978

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Idiopathic Thrombocytopenic Purpura
Antinuclear Antibodies
Splenectomy
gamma-Globulins
Indirect Fluorescent Antibody Technique
Lymphocyte Activation
Fluorescent Antibody Technique
Electrophoresis
Blood Platelets
Spleen
Immunoglobulin G
Bone Marrow
Wounds and Injuries
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparative immunological studies in ITP. / Burger, T.; Pár, A.; Schmelczer, M.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 35, No. 2, 1978, p. 141-146.

Research output: Contribution to journalArticle

Burger, T, Pár, A & Schmelczer, M 1978, 'Comparative immunological studies in ITP', Acta Medica Academiae Scientiarum Hungaricae, vol. 35, no. 2, pp. 141-146.
Burger, T. ; Pár, A. ; Schmelczer, M. / Comparative immunological studies in ITP. In: Acta Medica Academiae Scientiarum Hungaricae. 1978 ; Vol. 35, No. 2. pp. 141-146.
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