Comparative genomics reveals the origin of fungal hyphae and multicellularity

E. Kiss, Botond Hegedüs, Máté Virágh, Torda Varga, Zsolt Merényi, Tamás Kószó, Balázs Bálint, Arun N. Prasanna, Krisztina Krizsán, S. Kocsubé, Meritxell Riquelme, Norio Takeshita, László G. Nagy

Research output: Contribution to journalArticle

Abstract

Hyphae represent a hallmark structure of multicellular fungi. The evolutionary origins of hyphae and of the underlying genes are, however, hardly known. By systematically analyzing 72 complete genomes, we here show that hyphae evolved early in fungal evolution probably via diverse genetic changes, including co-option and exaptation of ancient eukaryotic (e.g. phagocytosis-related) genes, the origin of new gene families, gene duplications and alterations of gene structure, among others. Contrary to most multicellular lineages, the origin of filamentous fungi did not correlate with expansions of kinases, receptors or adhesive proteins. Co-option was probably the dominant mechanism for recruiting genes for hypha morphogenesis, while gene duplication was apparently less prevalent, except in transcriptional regulators and cell wall - related genes. We identified 414 novel gene families that show correlated evolution with hyphae and that may have contributed to its evolution. Our results suggest that hyphae represent a unique multicellular organization that evolved by limited fungal-specific innovations and gene duplication but pervasive co-option and modification of ancient eukaryotic functions.

Original languageEnglish
Number of pages1
JournalNature communications
Volume10
Issue number1
DOIs
Publication statusPublished - Sep 9 2019

Fingerprint

Hyphae
Genomics
genes
Genes
Gene Duplication
fungi
Fungi
Morphogenesis
Phagocytosis
Adhesives
Cell Wall
genome
Phosphotransferases
regulators
Genome
adhesives
Innovation
proteins
Cells
expansion

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Kiss, E., Hegedüs, B., Virágh, M., Varga, T., Merényi, Z., Kószó, T., ... Nagy, L. G. (2019). Comparative genomics reveals the origin of fungal hyphae and multicellularity. Nature communications, 10(1). https://doi.org/10.1038/s41467-019-12085-w

Comparative genomics reveals the origin of fungal hyphae and multicellularity. / Kiss, E.; Hegedüs, Botond; Virágh, Máté; Varga, Torda; Merényi, Zsolt; Kószó, Tamás; Bálint, Balázs; Prasanna, Arun N.; Krizsán, Krisztina; Kocsubé, S.; Riquelme, Meritxell; Takeshita, Norio; Nagy, László G.

In: Nature communications, Vol. 10, No. 1, 09.09.2019.

Research output: Contribution to journalArticle

Kiss, E, Hegedüs, B, Virágh, M, Varga, T, Merényi, Z, Kószó, T, Bálint, B, Prasanna, AN, Krizsán, K, Kocsubé, S, Riquelme, M, Takeshita, N & Nagy, LG 2019, 'Comparative genomics reveals the origin of fungal hyphae and multicellularity', Nature communications, vol. 10, no. 1. https://doi.org/10.1038/s41467-019-12085-w
Kiss, E. ; Hegedüs, Botond ; Virágh, Máté ; Varga, Torda ; Merényi, Zsolt ; Kószó, Tamás ; Bálint, Balázs ; Prasanna, Arun N. ; Krizsán, Krisztina ; Kocsubé, S. ; Riquelme, Meritxell ; Takeshita, Norio ; Nagy, László G. / Comparative genomics reveals the origin of fungal hyphae and multicellularity. In: Nature communications. 2019 ; Vol. 10, No. 1.
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