Comparative genomics reveals the origin of fungal hyphae and multicellularity

Enikő Kiss, Botond Hegedüs, Máté Virágh, Torda Varga, Zsolt Merényi, Tamás Kószó, Balázs Bálint, Arun N. Prasanna, Krisztina Krizsán, Sándor Kocsubé, Meritxell Riquelme, Norio Takeshita, László G. Nagy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hyphae represent a hallmark structure of multicellular fungi. The evolutionary origins of hyphae and of the underlying genes are, however, hardly known. By systematically analyzing 72 complete genomes, we here show that hyphae evolved early in fungal evolution probably via diverse genetic changes, including co-option and exaptation of ancient eukaryotic (e.g. phagocytosis-related) genes, the origin of new gene families, gene duplications and alterations of gene structure, among others. Contrary to most multicellular lineages, the origin of filamentous fungi did not correlate with expansions of kinases, receptors or adhesive proteins. Co-option was probably the dominant mechanism for recruiting genes for hypha morphogenesis, while gene duplication was apparently less prevalent, except in transcriptional regulators and cell wall - related genes. We identified 414 novel gene families that show correlated evolution with hyphae and that may have contributed to its evolution. Our results suggest that hyphae represent a unique multicellular organization that evolved by limited fungal-specific innovations and gene duplication but pervasive co-option and modification of ancient eukaryotic functions.

Original languageEnglish
Article number4080
JournalNature communications
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Comparative genomics reveals the origin of fungal hyphae and multicellularity'. Together they form a unique fingerprint.

  • Cite this

    Kiss, E., Hegedüs, B., Virágh, M., Varga, T., Merényi, Z., Kószó, T., Bálint, B., Prasanna, A. N., Krizsán, K., Kocsubé, S., Riquelme, M., Takeshita, N., & Nagy, L. G. (2019). Comparative genomics reveals the origin of fungal hyphae and multicellularity. Nature communications, 10(1), [4080]. https://doi.org/10.1038/s41467-019-12085-w