Comparative evaluation of surfactant and hydrophobizing agent concentration in relation to the optimal particle size of metered-dose inhalers

L. T. Fedina, R. Zelkó, L. I. Fedina, Zs Szabados, M. Szántó

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the present study was to formulate stabilized suspension- type metered-dose inhalation aerosols, and to examine the connection between the stabilizing additives and the optimal particle size. For the stabilization of the suspended particles, hydrophilic- and hydrophobic-type additives were applied. Oleil oleate was selected as a hydrophilic anionic surfactant, and the hydrophobizing agent was dimethyl siloxane polymer. The effect of the amount of the applied hydrophilic and hydrophobic additives on the optimal particle size was modeled by a second-order polynomial equation fitted to the data gathered by a face-centered central composite statistical design. We found that if the proper type and amount of additives are selected, it is possible to acquire the therapeutically best composition.

Original languageEnglish
Pages (from-to)853-856
Number of pages4
JournalDrug development and industrial pharmacy
Volume24
Issue number9
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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