Comparative evaluation of microcapsules prepared by fluidization atomization and melt coating process

I. Rácz, J. Dredán, I. Antal, E. Gondár

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Microcapsules were prepared from potassium chloride as a highly water-soluble model drug, and coated with white beeswax by the fluidization and melt methods. Dissolution profiles, microscopic surface topography, and diffusion reflectance spectra of microcapsules were evaluated by comparative studies. The results show remarkable differences in the examined parameters of the microcapsules prepared by different techniques. The results demonstrate that melt coating is able to control the drug release and may serve as an advantageous solvent-free alternative of fluidization.

Original languageEnglish
Pages (from-to)583-587
Number of pages5
JournalDrug Development and Industrial Pharmacy
Volume23
Issue number6
Publication statusPublished - 1997

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Fluidization
Atomization
Capsules
Coatings
Potassium Chloride
Surface diffusion
Surface topography
Pharmaceutical Preparations
Dissolution
Water

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

Comparative evaluation of microcapsules prepared by fluidization atomization and melt coating process. / Rácz, I.; Dredán, J.; Antal, I.; Gondár, E.

In: Drug Development and Industrial Pharmacy, Vol. 23, No. 6, 1997, p. 583-587.

Research output: Contribution to journalArticle

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