The genuine marker enzyme of primary nociceptive neurons, thiamine monophosphatase (TMPase) has been localized in the substantia gelatinosa of the rat spinal cord by means of light-and electron microscopic histochemistry; localization of substance P has been studied by light-and electron microscopic immunohistochemical methods. It has been shown that TMPase and substance P are located in two, regionally and structurally different populations of axon terminals. Substance P is contained both in Ad and in drC axons. In the postero-lateral funiculus of the white matter, substance P-positive axons establish axo-somatic synaptic contacts with large multipolar neurons of Cajal's interstitial nucleus.
ASJC Scopus subject areas
- Cell Biology