Comparative effects of glyceryl trinitrate on venous and arterial smooth muscle in vitro; relevance to antianginal activity

J. E. Mackenzie, J. Parratt

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Abstract

A quantitative in vitro study has been made of the actions of glyceryl trinitrate and sodium nitrite on vascular smooth muscle (dog femoral artery and saphenous vein; rat portal vein); these have been compared with the actions of papaverine, isoprenaline, salbutamol, pentaerythritol tetranitrate and trimetazidine. Glyceryl trinitrate was more active on the saphenous vein than on the femoral artery in inhibiting noradrenaline and potassium induced tone. Unlike glyceryl trinitrate, sodium nitrite and isoprenaline, papaverine and diazoxide inhibited noradrenaline induced contractions of venous and arterial smooth muscle to the same extent. The selective dilator effects of glyceryl trinitrate on venous smooth muscle may explain its action in alleviating the pain of angina pectoris. It is suggested that the use of these three vascular smooth muscle preparations (arterial, and veins with and without spontaneous myogenic activity) is a useful initial screening procedure for prospective antianginal drugs acting by venodilatation.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalBritish Journal of Pharmacology
Volume60
Issue number1
Publication statusPublished - 1977

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Nitroglycerin
Smooth Muscle
Sodium Nitrite
Papaverine
Saphenous Vein
Femoral Artery
Vascular Smooth Muscle
Isoproterenol
Pentaerythritol Tetranitrate
Norepinephrine
Trimetazidine
Diazoxide
Femoral Vein
Albuterol
Angina Pectoris
Portal Vein
Veins
Potassium
Dogs
Pain

ASJC Scopus subject areas

  • Pharmacology

Cite this

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N2 - A quantitative in vitro study has been made of the actions of glyceryl trinitrate and sodium nitrite on vascular smooth muscle (dog femoral artery and saphenous vein; rat portal vein); these have been compared with the actions of papaverine, isoprenaline, salbutamol, pentaerythritol tetranitrate and trimetazidine. Glyceryl trinitrate was more active on the saphenous vein than on the femoral artery in inhibiting noradrenaline and potassium induced tone. Unlike glyceryl trinitrate, sodium nitrite and isoprenaline, papaverine and diazoxide inhibited noradrenaline induced contractions of venous and arterial smooth muscle to the same extent. The selective dilator effects of glyceryl trinitrate on venous smooth muscle may explain its action in alleviating the pain of angina pectoris. It is suggested that the use of these three vascular smooth muscle preparations (arterial, and veins with and without spontaneous myogenic activity) is a useful initial screening procedure for prospective antianginal drugs acting by venodilatation.

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