Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance was investigated in a cross-over study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, V(d), AUD, t( 1/2 )) indicating that the two preparations are bioequivalent.
|Number of pages||4|
|Journal||International Journal of Clinical Pharmacology Therapy and Toxicology|
|Publication status||Published - Dec 1 1987|
ASJC Scopus subject areas
- Pharmacology (medical)