Comparative bioavailability study of two preparations of alpha-methyldopa after single, oral doses

K. Rona, B. Gachalyi, L. Vereczkey, B. Nadas, A. Kaldor

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance was investigated in a cross-over study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, V(d), AUD, t( 1/2 )) indicating that the two preparations are bioequivalent.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume25
Issue number9
Publication statusPublished - Dec 1 1987

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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