Comparative bioavailability of two different rectal preparations of piroxicam in man

S. Benkö, G. Grézal, E. Nagy, I. Klebovich

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Abstract

A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0-72 h), AUC, Cmax, t1/2β calculated from plasma concentration time curves, indicating that the two preparations were bioequivalent.

Original languageEnglish
Pages (from-to)315-317
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume43
Issue number3
DOIs
Publication statusPublished - Sep 1 1992

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Keywords

  • Piroxicam, NSAID
  • suppository, bioavailability, pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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