Comparative analysis of indices of central dopaminergic functions in man

G. Bagdy, Mihály Arató, Krisztina Baraczka, M. Fekete

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Various postulated indices of central dopaminergic activity - cerebrospinal fluid (CSF) dopamine (DA), dihydroxy-phenylacetic acid (DOPAC), homovanillic acid (HVA), noradrenaline (NA), plasma NA, serum prolactin, serum dopamine-β-hydroxylase (DBH), and platelet monoamine oxidase (MAO) activity - were measured in 30 drug-free inpatients. The mean values and the ranges were similar to those described in the literature. Plasma NA showed significant positive correlation with age. Significant positive correlation was found between CSF DA and its metabolites DOPAC and HVA. Serum DBH activity showed a slight but significant inverse correlation with CSF DA and its two metabolites. CSF NA showed a significant positive correlation with CSF DOPAC, but only in females. Serum DBH activity had no significant correlation either with CSF or with plasma NA levels. These findings suggest that either CSF HVA or DOPAC and DA may be useful indicators of DA metabolism in humans. Serum DBH activity may be in relationship with the central dopaminergic functions.

Original languageEnglish
Pages (from-to)2667-2676
Number of pages10
JournalLife Sciences
Volume32
Issue number23
DOIs
Publication statusPublished - Jun 6 1983

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Cerebrospinal fluid
Cerebrospinal Fluid
Dopamine
Norepinephrine
Homovanillic Acid
Serum
Metabolites
Plasmas
Monoamine Oxidase
Platelets
Mixed Function Oxygenases
Metabolism
Prolactin
Inpatients
Blood Platelets
phenylacetic acid
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Comparative analysis of indices of central dopaminergic functions in man. / Bagdy, G.; Arató, Mihály; Baraczka, Krisztina; Fekete, M.

In: Life Sciences, Vol. 32, No. 23, 06.06.1983, p. 2667-2676.

Research output: Contribution to journalArticle

Bagdy, G. ; Arató, Mihály ; Baraczka, Krisztina ; Fekete, M. / Comparative analysis of indices of central dopaminergic functions in man. In: Life Sciences. 1983 ; Vol. 32, No. 23. pp. 2667-2676.
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