Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis

Eszter Rausz, Agnes Szilágyi, Boguslaw Nedoszytko, Magdalena Lange, Marek Niedoszytko, Orsolya Lautner-Csorba, András Falus, István Aladzsity, Márta Kokai, Peter Valent, Márta Marschalko, Bernadett Hidvégi, József Szakonyi, Judit Csomor, Judit Várkonyi

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8 Citations (Scopus)

Abstract

Mastocytosis is a rare disease with reported high interleukin-6 (IL6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode IL6 and its receptor (IL6R) in relation to mastocytosis development in a case-control design. Analysis of the IL6R Asp358Ala polymorphism showed that carriers of the AA genotype had a 2·5-fold lower risk for mastocytosis than those with the AC or CC genotypes. No association with mastocytosis was found for the IL6-174G/C polymorphism, however, it may influence the effect of IL6R polymorphism. To the best of our knowledge this is the first study analysing IL6/IL6R polymorphisms in mastocytosis.

Original languageEnglish
Pages (from-to)216-219
Number of pages4
JournalBritish Journal of Haematology
Volume160
Issue number2
DOIs
Publication statusPublished - Jan 1 2013

Keywords

  • Genetic polymorphism
  • IL6
  • IL6R
  • Mastocytosis

ASJC Scopus subject areas

  • Hematology

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    Rausz, E., Szilágyi, A., Nedoszytko, B., Lange, M., Niedoszytko, M., Lautner-Csorba, O., Falus, A., Aladzsity, I., Kokai, M., Valent, P., Marschalko, M., Hidvégi, B., Szakonyi, J., Csomor, J., & Várkonyi, J. (2013). Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis. British Journal of Haematology, 160(2), 216-219. https://doi.org/10.1111/bjh.12086