2-es típusú diabetesesek és nem cukorbetegek területen szerzett, belgyógyászati osztályos felvételt igénylő bakteriális infekcióinak klinikai összehasonlítása

Translated title of the contribution: Community-acquired bacterial infections among type 2 diabetic and non-diabetic patients hospitalized on a general medical ward: a clinical comparison

László József Barkai, Emese Sipter, Dorottya Csuka, Tímea Baló, Zsuzsa Nébenführer, András Máthé, I. Karádi, P. Pánczél, Z. Prohászka, N. Hosszúfalusi

Research output: Contribution to journalArticle

Abstract

Introduction: Previous data showed bacterial infections among diabetic patients to be more serious and frequent, with higher mortality rates in comparison with non-diabetics. Recent investigations, however, are contradictory. Aim: The goal of our prospective, observational study was to compare patients hospitalized on a general medical ward due to community-acquired bacterial infections with type 2 diabetes mellitus (T2DM) to those of non-diabetics (K) by 1) infection localization, 2) spectrum of pathogens, 3) three-month mortality rates. Method: Patients were consecutively involved (T2DM: n = 205, K: n = 202). We characterized the infections, clinical parameters, mortalities of the two groups, and matched them to international data. Results: No difference regarding clinical details of the groups were found except for glycemic parameters and BMI. In the T2DM group the skin- and soft tissue- (37.1%), in the K patients respiratory infections (37.1%) were the most common, followed by urinary ones (31.2% and 31.7%, respectively). Skin- and soft tissue infection incidence among T2DM subjects were higher compared to international results (37.1% vs. 16%). Co-presence of Gram positive and Gram negative bacteria in the skin- and soft tissue infections (23/76 vs. 5/46, p = 0.0149), and polymicrobial origin in the urinary tract infections (34.0% vs. 15.1%, p = 0.0335) were found to be more frequent in T2DM than in K. No difference regarding mortality rates were detected. In T2DM the skin- and soft tissue while in the K group the respiratory infections had the most death counts. Conclusions: We found higher rates of skin- and soft tissue infections among T2DM patients hospitalized on a general medical ward compared to international data. In total we did not find difference regarding three-month mortality between the groups. Our results highlight the importance of primary prevention and shows its inadequacy concerning skin and soft tissue infections among type 2 diabetics in Hungary. Orv Hetil. 2019; 160(41): 1623-1632.

Original languageHungarian
Pages (from-to)1623-1632
Number of pages10
JournalOrvosi hetilap
Volume160
Issue number41
DOIs
Publication statusPublished - Oct 1 2019

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Community-Acquired Infections
Patients' Rooms
Bacterial Infections
Type 2 Diabetes Mellitus
Soft Tissue Infections
Skin
Mortality
Respiratory Tract Infections
Hungary
Primary Prevention
Infection
Gram-Negative Bacteria
Urinary Tract Infections
Observational Studies
Research Design
Prospective Studies
Incidence

ASJC Scopus subject areas

  • Medicine(all)

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2-es típusú diabetesesek és nem cukorbetegek területen szerzett, belgyógyászati osztályos felvételt igénylő bakteriális infekcióinak klinikai összehasonlítása. / Barkai, László József; Sipter, Emese; Csuka, Dorottya; Baló, Tímea; Nébenführer, Zsuzsa; Máthé, András; Karádi, I.; Pánczél, P.; Prohászka, Z.; Hosszúfalusi, N.

In: Orvosi hetilap, Vol. 160, No. 41, 01.10.2019, p. 1623-1632.

Research output: Contribution to journalArticle

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title = "2-es t{\'i}pus{\'u} diabetesesek {\'e}s nem cukorbetegek ter{\"u}leten szerzett, belgy{\'o}gy{\'a}szati oszt{\'a}lyos felv{\'e}telt ig{\'e}nylő bakteri{\'a}lis infekci{\'o}inak klinikai {\"o}sszehasonl{\'i}t{\'a}sa",
abstract = "Introduction: Previous data showed bacterial infections among diabetic patients to be more serious and frequent, with higher mortality rates in comparison with non-diabetics. Recent investigations, however, are contradictory. Aim: The goal of our prospective, observational study was to compare patients hospitalized on a general medical ward due to community-acquired bacterial infections with type 2 diabetes mellitus (T2DM) to those of non-diabetics (K) by 1) infection localization, 2) spectrum of pathogens, 3) three-month mortality rates. Method: Patients were consecutively involved (T2DM: n = 205, K: n = 202). We characterized the infections, clinical parameters, mortalities of the two groups, and matched them to international data. Results: No difference regarding clinical details of the groups were found except for glycemic parameters and BMI. In the T2DM group the skin- and soft tissue- (37.1{\%}), in the K patients respiratory infections (37.1{\%}) were the most common, followed by urinary ones (31.2{\%} and 31.7{\%}, respectively). Skin- and soft tissue infection incidence among T2DM subjects were higher compared to international results (37.1{\%} vs. 16{\%}). Co-presence of Gram positive and Gram negative bacteria in the skin- and soft tissue infections (23/76 vs. 5/46, p = 0.0149), and polymicrobial origin in the urinary tract infections (34.0{\%} vs. 15.1{\%}, p = 0.0335) were found to be more frequent in T2DM than in K. No difference regarding mortality rates were detected. In T2DM the skin- and soft tissue while in the K group the respiratory infections had the most death counts. Conclusions: We found higher rates of skin- and soft tissue infections among T2DM patients hospitalized on a general medical ward compared to international data. In total we did not find difference regarding three-month mortality between the groups. Our results highlight the importance of primary prevention and shows its inadequacy concerning skin and soft tissue infections among type 2 diabetics in Hungary. Orv Hetil. 2019; 160(41): 1623-1632.",
keywords = "2-es t{\'i}pus{\'u} cukorbetegs{\'e}g, bacterial infections, bakteri{\'a}lis fertőz{\'e}sek, bőr-{\'e}s l{\'a}gyr{\'e}sz-fertőz{\'e}sek, community-acquired infection, hal{\'a}loz{\'a}s, mortality, skin and soft tissue infections, ter{\"u}leten szerzett fertőz{\'e}sek, type 2 diabetes mellitus",
author = "Barkai, {L{\'a}szl{\'o} J{\'o}zsef} and Emese Sipter and Dorottya Csuka and T{\'i}mea Bal{\'o} and Zsuzsa N{\'e}benf{\"u}hrer and Andr{\'a}s M{\'a}th{\'e} and I. Kar{\'a}di and P. P{\'a}ncz{\'e}l and Z. Proh{\'a}szka and N. Hossz{\'u}falusi",
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TY - JOUR

T1 - 2-es típusú diabetesesek és nem cukorbetegek területen szerzett, belgyógyászati osztályos felvételt igénylő bakteriális infekcióinak klinikai összehasonlítása

AU - Barkai, László József

AU - Sipter, Emese

AU - Csuka, Dorottya

AU - Baló, Tímea

AU - Nébenführer, Zsuzsa

AU - Máthé, András

AU - Karádi, I.

AU - Pánczél, P.

AU - Prohászka, Z.

AU - Hosszúfalusi, N.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Introduction: Previous data showed bacterial infections among diabetic patients to be more serious and frequent, with higher mortality rates in comparison with non-diabetics. Recent investigations, however, are contradictory. Aim: The goal of our prospective, observational study was to compare patients hospitalized on a general medical ward due to community-acquired bacterial infections with type 2 diabetes mellitus (T2DM) to those of non-diabetics (K) by 1) infection localization, 2) spectrum of pathogens, 3) three-month mortality rates. Method: Patients were consecutively involved (T2DM: n = 205, K: n = 202). We characterized the infections, clinical parameters, mortalities of the two groups, and matched them to international data. Results: No difference regarding clinical details of the groups were found except for glycemic parameters and BMI. In the T2DM group the skin- and soft tissue- (37.1%), in the K patients respiratory infections (37.1%) were the most common, followed by urinary ones (31.2% and 31.7%, respectively). Skin- and soft tissue infection incidence among T2DM subjects were higher compared to international results (37.1% vs. 16%). Co-presence of Gram positive and Gram negative bacteria in the skin- and soft tissue infections (23/76 vs. 5/46, p = 0.0149), and polymicrobial origin in the urinary tract infections (34.0% vs. 15.1%, p = 0.0335) were found to be more frequent in T2DM than in K. No difference regarding mortality rates were detected. In T2DM the skin- and soft tissue while in the K group the respiratory infections had the most death counts. Conclusions: We found higher rates of skin- and soft tissue infections among T2DM patients hospitalized on a general medical ward compared to international data. In total we did not find difference regarding three-month mortality between the groups. Our results highlight the importance of primary prevention and shows its inadequacy concerning skin and soft tissue infections among type 2 diabetics in Hungary. Orv Hetil. 2019; 160(41): 1623-1632.

AB - Introduction: Previous data showed bacterial infections among diabetic patients to be more serious and frequent, with higher mortality rates in comparison with non-diabetics. Recent investigations, however, are contradictory. Aim: The goal of our prospective, observational study was to compare patients hospitalized on a general medical ward due to community-acquired bacterial infections with type 2 diabetes mellitus (T2DM) to those of non-diabetics (K) by 1) infection localization, 2) spectrum of pathogens, 3) three-month mortality rates. Method: Patients were consecutively involved (T2DM: n = 205, K: n = 202). We characterized the infections, clinical parameters, mortalities of the two groups, and matched them to international data. Results: No difference regarding clinical details of the groups were found except for glycemic parameters and BMI. In the T2DM group the skin- and soft tissue- (37.1%), in the K patients respiratory infections (37.1%) were the most common, followed by urinary ones (31.2% and 31.7%, respectively). Skin- and soft tissue infection incidence among T2DM subjects were higher compared to international results (37.1% vs. 16%). Co-presence of Gram positive and Gram negative bacteria in the skin- and soft tissue infections (23/76 vs. 5/46, p = 0.0149), and polymicrobial origin in the urinary tract infections (34.0% vs. 15.1%, p = 0.0335) were found to be more frequent in T2DM than in K. No difference regarding mortality rates were detected. In T2DM the skin- and soft tissue while in the K group the respiratory infections had the most death counts. Conclusions: We found higher rates of skin- and soft tissue infections among T2DM patients hospitalized on a general medical ward compared to international data. In total we did not find difference regarding three-month mortality between the groups. Our results highlight the importance of primary prevention and shows its inadequacy concerning skin and soft tissue infections among type 2 diabetics in Hungary. Orv Hetil. 2019; 160(41): 1623-1632.

KW - 2-es típusú cukorbetegség

KW - bacterial infections

KW - bakteriális fertőzések

KW - bőr-és lágyrész-fertőzések

KW - community-acquired infection

KW - halálozás

KW - mortality

KW - skin and soft tissue infections

KW - területen szerzett fertőzések

KW - type 2 diabetes mellitus

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