A nem alkoholos zsírmáj és az epekövesség együttes elofordulásának megfigyelése

Translated title of the contribution: Common occurence of non alcoholic fatty liver disease and cholecystolithiasis

Emil Fraenkel, Rita Takács, József Hamvas, G. Lengyel, J. Fehér

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Non Alcoholic Fatty Liver Disease is an acquired metabolic disease of the liver caused by accumulation of triglicerides in hepatocytes that is followed by necrobiotic inflammatory reaction, fibrosis and cirrhosis. Obesity, insulin resistance, diabetes mellitus and hyperlipidaemia are important pathogenetic factors of the process. It is known that among patients with cholecystolithiasis and diabetes mellitus in their anamnesis complications of cholecystolithiasis occur much more frequently like among patients without diabetes. Aim: The aim of the study is observation of the incidence of cholecystolithiasis and its complications in patients with Non Alcoholic Fatty Liver Disease and comparison of cholecystolithiasis incidence between healthy population and population with Non Alcoholic Fatty Liver Disease. Methods: Abdominal ultrasonographical findings were analysed in patients hospitalised at our department and in outpatients, patients with severe accompanied diseases were excluded of the analysis. The analysed basic file of patients could be considered as a selected file. The independence of the two examined variables was measured by χ 2 test. Results: Steatosis was described in 38% of the examined patients, cholecystolithiasis was described in 16% of patients. Cholecystolithiasis and its complications occur two times more frequently in patients with Non Alcoholic Fatty Liver Disease (33%) like Non Alcoholic Fatty Liver Disease in patients with cholecystolithiasis (16%). Complications of cholecystolithiasis occur more frequently among patients with Non Alcoholic Fatty Liver Disease like in healthy individuals. The χ2 test did not bring significant results concerning the independence of cholecystolithiasis and Non Alcoholic Fatty Liver Disease. Conclusion: Pathogenetic factors of Non Alcoholic Fatty Liver Disease participate in the pathogenesis of cholecystolithiasis. Their common pathogenetic factors bring about that the formation of cholecystolithiasis is probably faster than the progression of steatosis.

Original languageHungarian
Pages (from-to)793-798
Number of pages6
JournalOrvosi Hetilap
Volume148
Issue number17
DOIs
Publication statusPublished - Apr 29 2007

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Cholecystolithiasis
Diabetes Mellitus
Fibrosis
Non-alcoholic Fatty Liver Disease
Metabolic Diseases
Incidence
Hyperlipidemias
Population
Insulin Resistance
Hepatocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A nem alkoholos zsírmáj és az epekövesség együttes elofordulásának megfigyelése. / Fraenkel, Emil; Takács, Rita; Hamvas, József; Lengyel, G.; Fehér, J.

In: Orvosi Hetilap, Vol. 148, No. 17, 29.04.2007, p. 793-798.

Research output: Contribution to journalArticle

Fraenkel, Emil ; Takács, Rita ; Hamvas, József ; Lengyel, G. ; Fehér, J. / A nem alkoholos zsírmáj és az epekövesség együttes elofordulásának megfigyelése. In: Orvosi Hetilap. 2007 ; Vol. 148, No. 17. pp. 793-798.
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title = "A nem alkoholos zs{\'i}rm{\'a}j {\'e}s az epek{\"o}vess{\'e}g egy{\"u}ttes elofordul{\'a}s{\'a}nak megfigyel{\'e}se",
abstract = "Introduction: Non Alcoholic Fatty Liver Disease is an acquired metabolic disease of the liver caused by accumulation of triglicerides in hepatocytes that is followed by necrobiotic inflammatory reaction, fibrosis and cirrhosis. Obesity, insulin resistance, diabetes mellitus and hyperlipidaemia are important pathogenetic factors of the process. It is known that among patients with cholecystolithiasis and diabetes mellitus in their anamnesis complications of cholecystolithiasis occur much more frequently like among patients without diabetes. Aim: The aim of the study is observation of the incidence of cholecystolithiasis and its complications in patients with Non Alcoholic Fatty Liver Disease and comparison of cholecystolithiasis incidence between healthy population and population with Non Alcoholic Fatty Liver Disease. Methods: Abdominal ultrasonographical findings were analysed in patients hospitalised at our department and in outpatients, patients with severe accompanied diseases were excluded of the analysis. The analysed basic file of patients could be considered as a selected file. The independence of the two examined variables was measured by χ 2 test. Results: Steatosis was described in 38{\%} of the examined patients, cholecystolithiasis was described in 16{\%} of patients. Cholecystolithiasis and its complications occur two times more frequently in patients with Non Alcoholic Fatty Liver Disease (33{\%}) like Non Alcoholic Fatty Liver Disease in patients with cholecystolithiasis (16{\%}). Complications of cholecystolithiasis occur more frequently among patients with Non Alcoholic Fatty Liver Disease like in healthy individuals. The χ2 test did not bring significant results concerning the independence of cholecystolithiasis and Non Alcoholic Fatty Liver Disease. Conclusion: Pathogenetic factors of Non Alcoholic Fatty Liver Disease participate in the pathogenesis of cholecystolithiasis. Their common pathogenetic factors bring about that the formation of cholecystolithiasis is probably faster than the progression of steatosis.",
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AU - Takács, Rita

AU - Hamvas, József

AU - Lengyel, G.

AU - Fehér, J.

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N2 - Introduction: Non Alcoholic Fatty Liver Disease is an acquired metabolic disease of the liver caused by accumulation of triglicerides in hepatocytes that is followed by necrobiotic inflammatory reaction, fibrosis and cirrhosis. Obesity, insulin resistance, diabetes mellitus and hyperlipidaemia are important pathogenetic factors of the process. It is known that among patients with cholecystolithiasis and diabetes mellitus in their anamnesis complications of cholecystolithiasis occur much more frequently like among patients without diabetes. Aim: The aim of the study is observation of the incidence of cholecystolithiasis and its complications in patients with Non Alcoholic Fatty Liver Disease and comparison of cholecystolithiasis incidence between healthy population and population with Non Alcoholic Fatty Liver Disease. Methods: Abdominal ultrasonographical findings were analysed in patients hospitalised at our department and in outpatients, patients with severe accompanied diseases were excluded of the analysis. The analysed basic file of patients could be considered as a selected file. The independence of the two examined variables was measured by χ 2 test. Results: Steatosis was described in 38% of the examined patients, cholecystolithiasis was described in 16% of patients. Cholecystolithiasis and its complications occur two times more frequently in patients with Non Alcoholic Fatty Liver Disease (33%) like Non Alcoholic Fatty Liver Disease in patients with cholecystolithiasis (16%). Complications of cholecystolithiasis occur more frequently among patients with Non Alcoholic Fatty Liver Disease like in healthy individuals. The χ2 test did not bring significant results concerning the independence of cholecystolithiasis and Non Alcoholic Fatty Liver Disease. Conclusion: Pathogenetic factors of Non Alcoholic Fatty Liver Disease participate in the pathogenesis of cholecystolithiasis. Their common pathogenetic factors bring about that the formation of cholecystolithiasis is probably faster than the progression of steatosis.

AB - Introduction: Non Alcoholic Fatty Liver Disease is an acquired metabolic disease of the liver caused by accumulation of triglicerides in hepatocytes that is followed by necrobiotic inflammatory reaction, fibrosis and cirrhosis. Obesity, insulin resistance, diabetes mellitus and hyperlipidaemia are important pathogenetic factors of the process. It is known that among patients with cholecystolithiasis and diabetes mellitus in their anamnesis complications of cholecystolithiasis occur much more frequently like among patients without diabetes. Aim: The aim of the study is observation of the incidence of cholecystolithiasis and its complications in patients with Non Alcoholic Fatty Liver Disease and comparison of cholecystolithiasis incidence between healthy population and population with Non Alcoholic Fatty Liver Disease. Methods: Abdominal ultrasonographical findings were analysed in patients hospitalised at our department and in outpatients, patients with severe accompanied diseases were excluded of the analysis. The analysed basic file of patients could be considered as a selected file. The independence of the two examined variables was measured by χ 2 test. Results: Steatosis was described in 38% of the examined patients, cholecystolithiasis was described in 16% of patients. Cholecystolithiasis and its complications occur two times more frequently in patients with Non Alcoholic Fatty Liver Disease (33%) like Non Alcoholic Fatty Liver Disease in patients with cholecystolithiasis (16%). Complications of cholecystolithiasis occur more frequently among patients with Non Alcoholic Fatty Liver Disease like in healthy individuals. The χ2 test did not bring significant results concerning the independence of cholecystolithiasis and Non Alcoholic Fatty Liver Disease. Conclusion: Pathogenetic factors of Non Alcoholic Fatty Liver Disease participate in the pathogenesis of cholecystolithiasis. Their common pathogenetic factors bring about that the formation of cholecystolithiasis is probably faster than the progression of steatosis.

KW - Cholecystolithiasis

KW - Insulin resistance

KW - Non-Alcoholic Fatty Liver Disease

KW - Oxidative stress

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