Common mechanisms and holistic care in atherosclerosis and osteoporosis 11 Medical and Health Sciences 1103 Clinical Sciences

Z. Szekanecz, Hennie G. Raterman, Zsófia Petho, Willem F. Lems

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the aging population and even more in patients with inflammatory rheumatic diseases, such as rheumatoid arthritis, spondyloarthropathies, and systemic lupus erythematosus. In this review, we discuss how the epidemiology and pathogenesis of CV events and OP are overlapping. Smoking, diabetes mellitus, physical inactivity as conventional risk factors as well as systemic inflammation are among the modifiable risk factors for both CV events and bone loss. In rheumatic patients, systemic "high-grade" inflammation may be the primary driver of accelerated atherogenesis and bone resorption. In the general population, in which some individuals might have low-grade systemic inflammation, a holistic approach to drug treatment and lifestyle modifications may have beneficial effects on the bone as well as the vasculature. In rheumatic patients with accelerated inflammatory atherosclerosis and bone loss, the rapid and effective suppression of inflammation in a treat-to-target regime, aiming at clinical remission, is necessary to effectively control comorbidities.

Original languageEnglish
Article number15
JournalArthritis Research and Therapy
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 10 2019

Fingerprint

Osteoporosis
Atherosclerosis
Inflammation
Health
Bone and Bones
Spondylarthropathies
Bone Resorption
Rheumatic Diseases
Systemic Lupus Erythematosus
Population
Life Style
Comorbidity
Rheumatoid Arthritis
Diabetes Mellitus
Epidemiology
Cardiovascular Diseases
Smoking
Pharmaceutical Preparations
Therapeutics

Keywords

  • Atherosclerosis
  • Bone loss
  • DXA
  • Inflammation
  • Osteoporosis
  • Rheumatoid arthritis
  • Risk factors

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Common mechanisms and holistic care in atherosclerosis and osteoporosis 11 Medical and Health Sciences 1103 Clinical Sciences. / Szekanecz, Z.; Raterman, Hennie G.; Petho, Zsófia; Lems, Willem F.

In: Arthritis Research and Therapy, Vol. 21, No. 1, 15, 10.01.2019.

Research output: Contribution to journalReview article

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