Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe

B. Grallert, M. Sipiczki

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Cell division cycle mutants defective in G1, DNA replication or nuclear division were tested for sporulation at semi-restrictive temperatures. In cdc1-7, cdc5-120, cdc17-L16 and cdc18-46 no abnormalities were observed; cdc10-129, cdc20-M10, cdc21-M6B, cdc23-M36 and cdc24-M38 formed four-spored asci but with a low efficiency; cdc22-M45 was completely defective in meiosis, but could conjugate and formed zygotes with a single nucleus. Mutants defective in the mitotic initiation genes cdc2, cdc25 and cdc13 were blocked in meiosis II. None of the wee1-50, adh.nim1+ and win1+ alleles had any affect on sporulation, suggesting that their interactions with cdc25 and cdc2 are specific to mitosis. The meiotic function of cdc13 is TBZ-sensitive and probably exerted downstream of cdc2. Single mutants in cut1 or cut2 did not effect sporulation, whereas the double mutant cut1 cut2 formed two-spored asci. The results demonstrate that the cell division cycle and the meiotic developmental pathway share common genes and regulatory cascades.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalCurrent Genetics
Volume20
Issue number3
DOIs
Publication statusPublished - Aug 1 1991

Keywords

  • Cell division cycle
  • Fission yeast
  • Meiosis
  • Sporulation
  • cdc genes

ASJC Scopus subject areas

  • Genetics

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