Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila".

Peter Sonderegger, Laszlo Patthy

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

Didelot et al. (Reports, 11 August 2006, p. 851) claimed that Drosophila Tequila (Teq) and human neurotrypsin are orthologs and concluded that deficient long-term memory after Teq inactivation indicates that neurotrypsin plays its essential role for human cognitive functions through a similar mechanism. Our analyses suggest that Teq and neurotrypsin are not orthologous, leading us to question their equivalent roles in higher brain function.

Original languageEnglish
Pages (from-to)1698; author reply 1698
JournalScience (New York, N.Y.)
Volume316
Issue number5832
DOIs
Publication statusPublished - Jun 22 2007

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