Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage

Ferenc G. Rick, Luca Szalontay, Andrew V. Schally, Norman L. Block, Mehrdad Nadji, Karoly Szepeshazi, Irving Vidaurre, Marta Zarandi, Magdolna Kovacs, Zoltan Rekasi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose: Benign prostatic hyperplasia often affects aging men. Antagonists of the neuropeptide growth hormone-releasing hormone reduced prostate weight in an androgen induced benign prostatic hyperplasia model in rats. Luteinizing hormone-releasing hormone antagonists also produce marked, protracted improvement in lower urinary tract symptoms, reduced prostate volume and an increased urinary peak flow rate in men with benign prostatic hyperplasia. We investigated the influence of a combination of antagonists of growth hormone-releasing hormone and luteinizing hormone-releasing hormone on animal models of benign prostatic hyperplasia. Materials and Methods: We evaluated the effects of the growth hormone-releasing hormone antagonist JMR-132, given at a dose of 40 μg daily, the luteinizing hormone-releasing hormone antagonist cetrorelix, given at a dose of 0.625 mg/kg, and their combination on testosterone induced benign prostatic hyperplasia in adult male Wistar rats in vivo. Prostate tissue was examined biochemically and histologically. Serum levels of growth hormone, luteinizing hormone, insulin-like growth factor-1, dihydrotestosterone and prostate specific antigen were determined. Results: Marked shrinkage of the rat prostate (30.3%) occurred in response to the combination of growth hormone-releasing hormone and luteinizing hormone-releasing hormone antagonists (p

Original languageEnglish
Pages (from-to)1498-1504
Number of pages7
JournalJournal of Urology
Volume187
Issue number4
DOIs
Publication statusPublished - Apr 2012

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Hormone Antagonists
Growth Hormone-Releasing Hormone
Prostatic Hyperplasia
Gonadotropin-Releasing Hormone
Prostate
Lower Urinary Tract Symptoms
Dihydrotestosterone
Somatomedins
Prostate-Specific Antigen
Luteinizing Hormone
Neuropeptides
Androgens
Growth Hormone
Testosterone
Wistar Rats
Animal Models
Weights and Measures
Serum

Keywords

  • gonadotropin-releasing hormone
  • growth hormone-releasing hormone
  • inflammation
  • prostate
  • prostatic hyperplasia

ASJC Scopus subject areas

  • Urology

Cite this

Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage. / Rick, Ferenc G.; Szalontay, Luca; Schally, Andrew V.; Block, Norman L.; Nadji, Mehrdad; Szepeshazi, Karoly; Vidaurre, Irving; Zarandi, Marta; Kovacs, Magdolna; Rekasi, Zoltan.

In: Journal of Urology, Vol. 187, No. 4, 04.2012, p. 1498-1504.

Research output: Contribution to journalArticle

Rick, Ferenc G. ; Szalontay, Luca ; Schally, Andrew V. ; Block, Norman L. ; Nadji, Mehrdad ; Szepeshazi, Karoly ; Vidaurre, Irving ; Zarandi, Marta ; Kovacs, Magdolna ; Rekasi, Zoltan. / Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage. In: Journal of Urology. 2012 ; Vol. 187, No. 4. pp. 1498-1504.
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