Combined prognostic value of absolute lymphocyte/monocyte ratio in peripheral blood and interim PET/CT results in Hodgkin lymphoma

Zsofia Simon, S. Barna, Z. Miltenyi, K. Husi, F. Magyari, A. Jona, I. Garai, Z. Nagy, G. Ujj, L. Szerafin, A. Illes

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2 Citations (Scopus)

Abstract

Decreased absolute lymphocyte/monocyte ratio (LMR) in peripheral blood has been reported as an unfavorable prognostic marker in Hodgkin lymphoma. We aimed to investigate whether combining LMR and interim PET/CT scan result (PET2) confers stronger prognostic value than PET2 alone. 121 HL patients were investigated. LMR was calculated from a blood sample taken at the time of diagnosis. PET2 was carried out after the second chemotherapy cycle. Survival was calculated using the Kaplan–Meier method and significance was determined by log-rank test. Effect of variants on survival results was examined using univariate and multivariate analyses. Best LMR cut-off value was determined by receiver operating characteristic (ROC) curve. Best LMR cut-off value was 2.11 in the case of our patients (LMR >2.11: favorable, LMR ≤2.11: unfavorable). Overall and progression-free survivals (OS/PFS) were significantly worse both in lower LMR (≤2.11) (OS: P = 0.041, PFS: P = 0.044) and PET2 positive groups (OS: P < 0.001, PFS: P < 0.001). In PET2 positive patient group (n = 32) the low LMR result meant a significantly worse OS (0.030) and PFS (0.001). Both LMR and PET2 proved to be independent prognostic factors on multivariate analysis, and strengthened each other’s effect.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalInternational Journal of Hematology
Volume103
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Hodgkin lymphoma
  • Interim PET/CT
  • Lymphocyte/monocyte ratio
  • Prognostic marker

ASJC Scopus subject areas

  • Hematology

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