Female sex hormones affect venous pathology, but the effects of menopause and sex hormone replacement on the venous wall physiology have not been systematically studied. We examined the biomechanical changes of saphenous vein caused by depletion and replacement of sex hormones in female rats. 20 Sprague-Dawley rats were chemically ovariectomized by triptorelin. 10 of these received combined sex hormone replacement (HRT), the rest was given vehiculi. 10 animals without ovariectomy served as controls. After 12 weeks of treatment, a segment of the saphenous vein was dissected. Pressure-diameter curves were recorded in relaxed, contracted and control states by a microangiograph. Compared to control (2.9±0.7*10-4N/m2), ovariectomy lowered wall distensibility measured in contraction (7±0.85*10-5 N/m2). HRT partly restored this value (1.3*0.78*10-4N/m2; data given on the pressure level P=8 mmHg; p<0.05 between the groups). No elastic alteration was found in relaxation. We demonstrated significantly decreased distensibility of the saphenous vein after sex hormone depletion, which show disturbed venous capacitance function. HRT prevented these alterations. Because of unaltered passive distensibility and venous wall mass volume we propose changes of contractile elements of the saphenous vein.
|Translated title of the contribution||Combined hormone replacement therapy reverses decreased venous distensibility of saphenous vein in a rat menopause model|
|Number of pages||6|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2002|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology