Combined effect of pore radius and protein dielectric coefficient on the selectivity of a calcium channel

Dezso Boda, Mónika Valiskó, Bob Eisenberg, Wolfgang Nonner, Douglas Henderson, Dirk Gillespie

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Calcium-selective ion channels often contain a selectivity filter made of similar amino acids, rich in carboxlylates, although the Ca2+ affinities of these channels range from micromolar to millimolar. To understand the physical mechanism for this range of affinities, we use grand canonical Monte Carlo simulations to study the competition of Na+ and Ca2+ in the selectivity filter of a reduced model of a Ca channel. We show that Ca2+ affinity is increased dramatically when both the volume and dielectric coefficient of the protein are reduced.

Original languageEnglish
Article number168102
JournalPhysical review letters
Volume98
Issue number16
DOIs
Publication statusPublished - Apr 17 2007

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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