Combined effect of cytostatic drugs and E-N-L-trimethyl lysine in healthy and transplantable tumor bearing mice

B. Szende, K. Lapis, K. Simon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

E-N-L-trimethyl lysine (TML) decreases the toxicity of Vincristin, Cyclophosphamide and Doxorubicin (Adriamycin) when administered simultaneously to healthy mice. Simultaneous treatment of L1210 ascites leukemia bearing mice with 100 mg/kg TML and 2, 2.5, 3.2, 3.5, 4 mg/kg Vincristin or 10, 15, 20 mg/kg Doxorubicin increases significantly the survival of the animals when compared with untreated and Vincristin or Doxorubicin treated mice. Repeated impulse treatment of S-180 subcutaneous sarcoma with 100 mg/kg TML and 50-100 mg/kg Cyclophosphamide results in a significantly higher survival time and rate than Cyclophosphamide treatment alone.

Original languageEnglish
Pages (from-to)427-439
Number of pages13
JournalNeoplasma
Volume29
Issue number4
Publication statusPublished - Dec 1 1982

ASJC Scopus subject areas

  • Cancer Research

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