Combinatorial glycomics 1

Synthesis options

Boglárka Dönczo, László Kalmár, János Kerékgyártó, Zoltán Szurmai, A. Guttman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The viral-surface envelope glycoproteins of HIV are abundantly decorated with complex and high mannose type N-glycans (> 20 glycosylation sites). Synthesis of a large number of closely related structural determinants of high mannose antennae was carried out by means of the combination of conventional and combinatorial carbohydrate chemistry. The chitobiose part of the core structure was replaced by a simple octyl aglycone. The pseudo tetra-(2) and penta-(3)-saccharides were prepared by standard carbohydrate chemistry. The p-mannosidic linkage was created by the oxidation-reduction technique. Random mannosylation of acceptors 2 and 3 resulted in a mixture of predominantly pseudo penta-and hexasaccharides, respectively. After removal of the protecting groups, the interaction of the synthesized mixture of oligosaccharides and gp120 binding proteins will be investigated.

Original languageEnglish
JournalChemicke Listy
Volume107
Issue number3
Publication statusPublished - 2013

Fingerprint

Mannose
Carbohydrates
Glycosylation
Oligosaccharides
Polysaccharides
Glycoproteins
Carrier Proteins
Antennas
Glycomics
Oxidation-Reduction
chitobiose

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Dönczo, B., Kalmár, L., Kerékgyártó, J., Szurmai, Z., & Guttman, A. (2013). Combinatorial glycomics 1: Synthesis options. Chemicke Listy, 107(3).

Combinatorial glycomics 1 : Synthesis options. / Dönczo, Boglárka; Kalmár, László; Kerékgyártó, János; Szurmai, Zoltán; Guttman, A.

In: Chemicke Listy, Vol. 107, No. 3, 2013.

Research output: Contribution to journalArticle

Dönczo, B, Kalmár, L, Kerékgyártó, J, Szurmai, Z & Guttman, A 2013, 'Combinatorial glycomics 1: Synthesis options', Chemicke Listy, vol. 107, no. 3.
Dönczo B, Kalmár L, Kerékgyártó J, Szurmai Z, Guttman A. Combinatorial glycomics 1: Synthesis options. Chemicke Listy. 2013;107(3).
Dönczo, Boglárka ; Kalmár, László ; Kerékgyártó, János ; Szurmai, Zoltán ; Guttman, A. / Combinatorial glycomics 1 : Synthesis options. In: Chemicke Listy. 2013 ; Vol. 107, No. 3.
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