Combinatorial glycomics 1: Synthesis options

Boglárka Dönczo, László Kalmár, János Kerékgyártó, Zoltán Szurmai, András Guttman

Research output: Contribution to journalConference article

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Abstract

The viral-surface envelope glycoproteins of HIV are abundantly decorated with complex and high mannose type N-glycans (> 20 glycosylation sites). Synthesis of a large number of closely related structural determinants of high mannose antennae was carried out by means of the combination of conventional and combinatorial carbohydrate chemistry. The chitobiose part of the core structure was replaced by a simple octyl aglycone. The pseudo tetra-(2) and penta-(3)-saccharides were prepared by standard carbohydrate chemistry. The p-mannosidic linkage was created by the oxidation-reduction technique. Random mannosylation of acceptors 2 and 3 resulted in a mixture of predominantly pseudo penta-and hexasaccharides, respectively. After removal of the protecting groups, the interaction of the synthesized mixture of oligosaccharides and gp120 binding proteins will be investigated.

Original languageEnglish
Pages (from-to)s353-s354
JournalChemicke Listy
Volume107
Issue number3
Publication statusPublished - Dec 1 2013
EventCECE Junior 2013 - Brno, Czech Republic
Duration: Nov 12 2013Nov 13 2013

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Dönczo, B., Kalmár, L., Kerékgyártó, J., Szurmai, Z., & Guttman, A. (2013). Combinatorial glycomics 1: Synthesis options. Chemicke Listy, 107(3), s353-s354.