Combination of zinc hyaluronate and metronidazole in a lipid-based drug delivery system for the treatment of periodontitis

Attila Léber, Mária Budai Szȕcs, Edit Urbán, Péter Vályi, Attila Gácsi, Szilvia Berkó, Anita Kovács, Erzsébet Csányi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Despite being a highly prevalent disease and a possible contributor to adult tooth loss, periodontitis possesses no well-established therapy. The aim of the recent study was the development and evaluation of a mucoadhesive monophase lipid formulation for the sustained local delivery of amoxicillin, metronidazole, and/or zinc hyaluronate or gluconate. Methods: To investigate our formulations, differential scanning calorimetry, X-ray diffraction, swelling, erosion, mucoadhesivity, drug release, and antimicrobial measurements were performed. Results: Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) results show that the loaded drugs are in a suspended form, the softening of the formulations starts at body temperature, but a part remains solid, providing sustained release. Swelling of the lipid compositions is affected by the hydrophilic components, their concentration, and the strength of the coherent lipid structure, while their erosion is impacted by the emulsification of melted lipid components. Conclusions: Results of drug release and antimicrobial effectiveness measurements show that a sustained release may be obtained. Amoxicillin had higher effectiveness against oral pathogens than metronidazole or zinc hyaluronate alone, but the combination of the two latter could provide similar effectiveness to amoxicillin. The applied mucoadhesive polymer may affect adhesivity, drug release through the swelling mechanism, and antimicrobial effect as well.

Original languageEnglish
Article number142
JournalPharmaceutics
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Amoxicillin
  • Lipid drug delivery
  • Metronidazole
  • Periodontitis
  • Zinc hyaluronate

ASJC Scopus subject areas

  • Pharmaceutical Science

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