Column selection for pharmaceutical analyses based on a column classification using four test parameters

Kristóf Kóczián, Erik Haghedooren, Sanja Dragovic, B. Noszál, Jos Hoogmartens, Erwin Adams

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This paper focuses on the usability of a previously developed column classification system, applied to pharmaceutical analyses. The separation of two drugs from their respective related substances was investigated on 65 new reversed-phase liquid chromatographic columns. The chromatographic procedure for fluoxetine hydrochloride was performed according to the method prescribed in the European Pharmacopoeia monograph while the separation of gemcitabine hydrochloride was carried out according to the United States Pharmacopeia monograph. It was shown that the column ranking system is a helpful tool in the selection of a suitable column.

Original languageEnglish
Pages (from-to)894-905
Number of pages12
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume44
Issue number4
DOIs
Publication statusPublished - Aug 15 2007

Fingerprint

Pharmacopoeias
gemcitabine
Fluoxetine
Pharmaceutical Preparations
Liquids

Keywords

  • Chromatographic tests
  • Column ranking
  • Fluoxetine
  • Gemcitabine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

Column selection for pharmaceutical analyses based on a column classification using four test parameters. / Kóczián, Kristóf; Haghedooren, Erik; Dragovic, Sanja; Noszál, B.; Hoogmartens, Jos; Adams, Erwin.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 44, No. 4, 15.08.2007, p. 894-905.

Research output: Contribution to journalArticle

Kóczián, Kristóf ; Haghedooren, Erik ; Dragovic, Sanja ; Noszál, B. ; Hoogmartens, Jos ; Adams, Erwin. / Column selection for pharmaceutical analyses based on a column classification using four test parameters. In: Journal of Pharmaceutical and Biomedical Analysis. 2007 ; Vol. 44, No. 4. pp. 894-905.
@article{ec8ba11bd6d5488d9824d39950d23229,
title = "Column selection for pharmaceutical analyses based on a column classification using four test parameters",
abstract = "This paper focuses on the usability of a previously developed column classification system, applied to pharmaceutical analyses. The separation of two drugs from their respective related substances was investigated on 65 new reversed-phase liquid chromatographic columns. The chromatographic procedure for fluoxetine hydrochloride was performed according to the method prescribed in the European Pharmacopoeia monograph while the separation of gemcitabine hydrochloride was carried out according to the United States Pharmacopeia monograph. It was shown that the column ranking system is a helpful tool in the selection of a suitable column.",
keywords = "Chromatographic tests, Column ranking, Fluoxetine, Gemcitabine",
author = "Krist{\'o}f K{\'o}czi{\'a}n and Erik Haghedooren and Sanja Dragovic and B. Nosz{\'a}l and Jos Hoogmartens and Erwin Adams",
year = "2007",
month = "8",
day = "15",
doi = "10.1016/j.jpba.2007.04.015",
language = "English",
volume = "44",
pages = "894--905",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
issn = "0731-7085",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Column selection for pharmaceutical analyses based on a column classification using four test parameters

AU - Kóczián, Kristóf

AU - Haghedooren, Erik

AU - Dragovic, Sanja

AU - Noszál, B.

AU - Hoogmartens, Jos

AU - Adams, Erwin

PY - 2007/8/15

Y1 - 2007/8/15

N2 - This paper focuses on the usability of a previously developed column classification system, applied to pharmaceutical analyses. The separation of two drugs from their respective related substances was investigated on 65 new reversed-phase liquid chromatographic columns. The chromatographic procedure for fluoxetine hydrochloride was performed according to the method prescribed in the European Pharmacopoeia monograph while the separation of gemcitabine hydrochloride was carried out according to the United States Pharmacopeia monograph. It was shown that the column ranking system is a helpful tool in the selection of a suitable column.

AB - This paper focuses on the usability of a previously developed column classification system, applied to pharmaceutical analyses. The separation of two drugs from their respective related substances was investigated on 65 new reversed-phase liquid chromatographic columns. The chromatographic procedure for fluoxetine hydrochloride was performed according to the method prescribed in the European Pharmacopoeia monograph while the separation of gemcitabine hydrochloride was carried out according to the United States Pharmacopeia monograph. It was shown that the column ranking system is a helpful tool in the selection of a suitable column.

KW - Chromatographic tests

KW - Column ranking

KW - Fluoxetine

KW - Gemcitabine

UR - http://www.scopus.com/inward/record.url?scp=34547110844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547110844&partnerID=8YFLogxK

U2 - 10.1016/j.jpba.2007.04.015

DO - 10.1016/j.jpba.2007.04.015

M3 - Article

C2 - 17531419

AN - SCOPUS:34547110844

VL - 44

SP - 894

EP - 905

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

SN - 0731-7085

IS - 4

ER -