Heterogén vastagbéldaganat: a fogazott tvonalon kialakuló, sporadikus laesiók jelentosége a klinikai gyakorlatban

Translated title of the contribution: Colorectal cancer heterogeneity: The clinical impact of sporadic lesions arising via the serrated pathway

Agoston Emese Irma, Horváth Evelin, Gyorffy Balázs, Harsányi László, Szász A. Marcell

Research output: Contribution to journalReview article

Abstract

Today, colorectal cancer is regarded as a heterogeneous disease. Its heterogeneity is caused by genetic alterations, molecular aberrations, different developing pathways as well as by micro- and macroenviromental agents. In the last decade, beside the classic genetic model for colorectal tumuorgenesis that follows the adenoma-carcinoma sequence, an alternative pathway has been identified. This pathway is called the serrated pathway and it is responsible for approximately one third of all colorectal lesions. Beyond their dissimilar molecular characteristics, these tumours also show different macroscopic and histologic appearance. Moreover, their malignant potency and progressive ability distinguish them from tumours of the classic genetic model. The aim of this review is to summarize the molecular and pathologic features of serrated lesions and the serrated pathway to colorectal cancer and to highlight their clinical impact.

Original languageHungarian
Pages (from-to)206-214
Number of pages9
JournalOrvosi Hetilap
Volume159
Issue number6
DOIs
Publication statusPublished - Feb 1 2018

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Genetic Models
Colorectal Neoplasms
Adenoma
Molecular Biology
Neoplasms
Carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Heterogén vastagbéldaganat : a fogazott tvonalon kialakuló, sporadikus laesiók jelentosége a klinikai gyakorlatban. / Irma, Agoston Emese; Evelin, Horváth; Balázs, Gyorffy; László, Harsányi; Marcell, Szász A.

In: Orvosi Hetilap, Vol. 159, No. 6, 01.02.2018, p. 206-214.

Research output: Contribution to journalReview article

Irma, Agoston Emese ; Evelin, Horváth ; Balázs, Gyorffy ; László, Harsányi ; Marcell, Szász A. / Heterogén vastagbéldaganat : a fogazott tvonalon kialakuló, sporadikus laesiók jelentosége a klinikai gyakorlatban. In: Orvosi Hetilap. 2018 ; Vol. 159, No. 6. pp. 206-214.
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AB - Today, colorectal cancer is regarded as a heterogeneous disease. Its heterogeneity is caused by genetic alterations, molecular aberrations, different developing pathways as well as by micro- and macroenviromental agents. In the last decade, beside the classic genetic model for colorectal tumuorgenesis that follows the adenoma-carcinoma sequence, an alternative pathway has been identified. This pathway is called the serrated pathway and it is responsible for approximately one third of all colorectal lesions. Beyond their dissimilar molecular characteristics, these tumours also show different macroscopic and histologic appearance. Moreover, their malignant potency and progressive ability distinguish them from tumours of the classic genetic model. The aim of this review is to summarize the molecular and pathologic features of serrated lesions and the serrated pathway to colorectal cancer and to highlight their clinical impact.

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