Colloidal stability of carboxylated iron oxide nanomagnets for biomedical use

Etelka Tombácz, Márta Szekeres, Angéla Hajdú, Ildikó Y. Tóth, Rita Andrea Bauer, Dániel Nesztor, Erzsébet Illés, István Zupkó, Ladislau Vékás

Research output: Contribution to journalArticle

11 Citations (Scopus)


Magnetite nanoparticles (MNP) were synthesized and stabilized with carboxylated compounds citric acid - CA, poly(acrylic acid) - PAA, poly(acrylic acid-co-maleic acid) - PAM, humic acid - HA and gallic acid - GA (polymerizing in situ on the surface). Adsorption isotherms and bonding feature were determined and used to explain the changes in charge and aggregation states and salt tolerance of the MNPs. The thicker layer of macromolecular acids PAA, PAM and HA provides better stability at physiological pH and salt concentration compared to the CA and GA coatings. In addition, Fe(III)-CA complexation promotes the dissolution of the nanoparticles. The biocompatibility of the polyacid-coated MNPs was tested in cell proliferation experiments.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalPeriodica Polytechnica Chemical Engineering
Issue numberSUPPL
Publication statusPublished - 2014


  • Adsorption
  • Biocompatibility
  • Carboxylated magnetite nanoparticles
  • Nanoparticle stabilization
  • Overcharging
  • Small and macromolecular organic polyacids

ASJC Scopus subject areas

  • Chemical Engineering(all)

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