Collagen antibody-induced arthritis: A disease-relevant model for studies of persistent joint pain

K. Sándor, Kutty Selva Nandakumar, Rikard Holmdahl, Camilla I. Svensson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Rheumatoid arthritis (RA) is a complex autoimmune disease, with a prevalence of approximately 1% in the population worldwide. RA is a chronic inflammatory disease primarily affecting joints and patients suffer from a plethora of symptoms, including pain, fatigue and stiffness. Joint pain is one of the most egregious symptoms in RA. Animal models of RA are used extensively in research to understand the pathogenesis of inflammatory arthritis and in the assessment of potential disease-modifying agents. There is an increasing need for disease-relevant animal models for pain research and several of the RA animal models that previously were not used in pain research have now been characterized for this purpose. The most commonly used RA model is the collagen-induced arthritis (CIA) model. However, it has certain disadvantages when used for pain research. Here we describe an alternative model, the collagen antibody-induced arthritis (CAIA) model to study RA-induced pain. This model has been used to investigate disease pathology for more than 10 years, but has just recently been characterized as a pain model. In comparison to CIA, more mouse strains are susceptible to CAIA and the degree of joint pathology and systemic disease is less severe, making the assessment of arthritis-associated nociceptive behavior, such as paw withdrawal from mechanical or thermal stimuli, as well as changes in normal behavior such as locomotion more easily investigated. The aim of this chapter is to describe the CAIA model and several techniques used to study inflammatory pain-like behavior.

Original languageEnglish
Title of host publicationMethods in Pharmacology and Toxicology
Pages437-455
Number of pages19
DOIs
Publication statusPublished - 2012

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)15572153
ISSN (Electronic)19406053

Fingerprint

Experimental Arthritis
Arthralgia
Rheumatoid Arthritis
Pain
Antibodies
Research
Arthritis
Animal Models
Joints
Pathology
Animal Disease Models
Locomotion
Autoimmune Diseases
Fatigue
Chronic Disease
Hot Temperature
Population

Keywords

  • Chronic pain
  • Collagen antibody-induced arthritis
  • Mechanical hypersensitivity
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Molecular Medicine
  • Pharmacology (medical)

Cite this

Sándor, K., Nandakumar, K. S., Holmdahl, R., & Svensson, C. I. (2012). Collagen antibody-induced arthritis: A disease-relevant model for studies of persistent joint pain. In Methods in Pharmacology and Toxicology (pp. 437-455). (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-62703-095-3_27

Collagen antibody-induced arthritis : A disease-relevant model for studies of persistent joint pain. / Sándor, K.; Nandakumar, Kutty Selva; Holmdahl, Rikard; Svensson, Camilla I.

Methods in Pharmacology and Toxicology. 2012. p. 437-455 (Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sándor, K, Nandakumar, KS, Holmdahl, R & Svensson, CI 2012, Collagen antibody-induced arthritis: A disease-relevant model for studies of persistent joint pain. in Methods in Pharmacology and Toxicology. Methods in Pharmacology and Toxicology, pp. 437-455. https://doi.org/10.1007/978-1-62703-095-3_27
Sándor K, Nandakumar KS, Holmdahl R, Svensson CI. Collagen antibody-induced arthritis: A disease-relevant model for studies of persistent joint pain. In Methods in Pharmacology and Toxicology. 2012. p. 437-455. (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-62703-095-3_27
Sándor, K. ; Nandakumar, Kutty Selva ; Holmdahl, Rikard ; Svensson, Camilla I. / Collagen antibody-induced arthritis : A disease-relevant model for studies of persistent joint pain. Methods in Pharmacology and Toxicology. 2012. pp. 437-455 (Methods in Pharmacology and Toxicology).
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