Coherent diffraction imaging: Consistency of the assembled three-dimensional distribution

Research output: Contribution to journalArticle

4 Citations (Scopus)


The short pulses of X-ray free-electron lasers can produce diffraction patterns with structural information before radiation damage destroys the particle. From the recorded diffraction patterns the structure of particles or molecules can be determined on the nano- or even atomic scale. In a coherent diffraction imaging experiment thousands of diffraction patterns of identical particles are recorded and assembled into a three-dimensional distribution which is subsequently used to solve the structure of the particle. It is essential to know, but not always obvious, that the assembled three-dimensional reciprocal-space intensity distribution is really consistent with the measured diffraction patterns. This paper shows that, with the use of correlation maps and a single parameter calculated from them, the consistency of the three-dimensional distribution can be reliably validated.

Original languageEnglish
Pages (from-to)459-464
Number of pages6
JournalActa Crystallographica Section A: Foundations and Advances
Issue number4
Publication statusPublished - Jul 1 2016



  • coherent diffraction imaging
  • orientation
  • single-particle imaging
  • X-ray free-electron lasers
  • XFELs

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Science(all)
  • Structural Biology
  • Inorganic Chemistry
  • Condensed Matter Physics
  • Biochemistry

Cite this