Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10

I. Lekli, Somak Das, Samarjit Das, Subhendu Mukherjee, I. Bak, B. Juhász, Debasis Bagchi, Golakoti Trimurtulu, A. V. Krishnaraju, Krishanu Sengupta, A. Tósaki, Dipak K. Das

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Coenzyme Q10 (CoQ10) has been extensively studied as adjunctive therapy for ischemic heart disease, and its cardioprotective ability is well-established. The mitochondrial respiratory chain contains several coenzymes, including CoQ1, CoQ2, CoQ4, CoQ 6, CoQ7, CoQ8, CoQ9, and CoQ 10. It is not known whether other CoQs, especially CoQ9, is equally cardioprotective as CoQ10. The present study was designed to determine if CoQ9 could protect guinea pig hearts from ischemia reperfusion injury. Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ9 and CoQ10, respectively, for 30 days while group III served as control. After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion. Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis. Samples of hearts were examined for the presence of CoQ9 and CoQ10. The results demonstrated that both CoQ9 and CoQ10 were equally cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis. High performance liquid chromatographic (HPLC) analysis revealed that a substantial portion of CoQ9 had been converted into CoQ10. The results indicate that CoQ9 by itself, or after being converted into CoQ10, reduced myocardial ischemia/reperfusion-induced injury.

Original languageEnglish
Pages (from-to)5331-5337
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume56
Issue number13
DOIs
Publication statusPublished - Jul 9 2008

Fingerprint

coenzyme Q10
coenzymes
guinea pigs
Guinea Pigs
myocardial infarction
heart
myocardial ischemia
ischemia
Reperfusion Injury
Cardiac Myocytes
Myocardial Ischemia
apoptosis
Myocardial Infarction
Apoptosis
Myocardial Reperfusion
ubiquinone 9
arrhythmia
Coenzymes
electron transport chain
High performance liquid chromatography

Keywords

  • Coenzyme Q
  • Coenzyme Q
  • Heart
  • Ischemic reperfusion injury

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

Cite this

Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10 . / Lekli, I.; Das, Somak; Das, Samarjit; Mukherjee, Subhendu; Bak, I.; Juhász, B.; Bagchi, Debasis; Trimurtulu, Golakoti; Krishnaraju, A. V.; Sengupta, Krishanu; Tósaki, A.; Das, Dipak K.

In: Journal of Agricultural and Food Chemistry, Vol. 56, No. 13, 09.07.2008, p. 5331-5337.

Research output: Contribution to journalArticle

Lekli, I, Das, S, Das, S, Mukherjee, S, Bak, I, Juhász, B, Bagchi, D, Trimurtulu, G, Krishnaraju, AV, Sengupta, K, Tósaki, A & Das, DK 2008, 'Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10 ', Journal of Agricultural and Food Chemistry, vol. 56, no. 13, pp. 5331-5337. https://doi.org/10.1021/jf800035f
Lekli, I. ; Das, Somak ; Das, Samarjit ; Mukherjee, Subhendu ; Bak, I. ; Juhász, B. ; Bagchi, Debasis ; Trimurtulu, Golakoti ; Krishnaraju, A. V. ; Sengupta, Krishanu ; Tósaki, A. ; Das, Dipak K. / Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10 In: Journal of Agricultural and Food Chemistry. 2008 ; Vol. 56, No. 13. pp. 5331-5337.
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AU - Bagchi, Debasis

AU - Trimurtulu, Golakoti

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N2 - Coenzyme Q10 (CoQ10) has been extensively studied as adjunctive therapy for ischemic heart disease, and its cardioprotective ability is well-established. The mitochondrial respiratory chain contains several coenzymes, including CoQ1, CoQ2, CoQ4, CoQ 6, CoQ7, CoQ8, CoQ9, and CoQ 10. It is not known whether other CoQs, especially CoQ9, is equally cardioprotective as CoQ10. The present study was designed to determine if CoQ9 could protect guinea pig hearts from ischemia reperfusion injury. Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ9 and CoQ10, respectively, for 30 days while group III served as control. After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion. Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis. Samples of hearts were examined for the presence of CoQ9 and CoQ10. The results demonstrated that both CoQ9 and CoQ10 were equally cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis. High performance liquid chromatographic (HPLC) analysis revealed that a substantial portion of CoQ9 had been converted into CoQ10. The results indicate that CoQ9 by itself, or after being converted into CoQ10, reduced myocardial ischemia/reperfusion-induced injury.

AB - Coenzyme Q10 (CoQ10) has been extensively studied as adjunctive therapy for ischemic heart disease, and its cardioprotective ability is well-established. The mitochondrial respiratory chain contains several coenzymes, including CoQ1, CoQ2, CoQ4, CoQ 6, CoQ7, CoQ8, CoQ9, and CoQ 10. It is not known whether other CoQs, especially CoQ9, is equally cardioprotective as CoQ10. The present study was designed to determine if CoQ9 could protect guinea pig hearts from ischemia reperfusion injury. Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ9 and CoQ10, respectively, for 30 days while group III served as control. After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion. Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis. Samples of hearts were examined for the presence of CoQ9 and CoQ10. The results demonstrated that both CoQ9 and CoQ10 were equally cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis. High performance liquid chromatographic (HPLC) analysis revealed that a substantial portion of CoQ9 had been converted into CoQ10. The results indicate that CoQ9 by itself, or after being converted into CoQ10, reduced myocardial ischemia/reperfusion-induced injury.

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