Coeliac disease

Always something to discover

A. Várkonyi, M. Boda, E. Endreffy, I. Németh, E. Timár

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The authors present more than 20 years' experience with coeliac disease, with a summary of their published studies. Hair shaft characteristics were determined by scanning electron microscopy. Hair diameter was significantly lower and cuticular erosion scores higher in those who were not on gluten- free diets as compared to controls, showing a tendency towards normal values following start of gluten-free diets. Proton-induced X-ray emission showed significantly lower zinc content of the hair shaft in the group with acute coeliac disease and after a short-term diet, which approached the normal range only after a yearlong diet. The serum prolactin levels in healthy controls and in coeliac patients on the diet were within normal limits, whereas in children with coeliac disease taking gluten in their meals, a significant hyperprolactinaemia was found. The erythrocyte glutathione content of coeliac children was elevated, and the glutathione disulfide level was significantly decreased, as compared to values in normal controls. The erythrocyte glutathione disulfide level and glutathione disulfide/erythrocyte glutathione ratio in coeliac children also differed from those in children with iron deficiency. With genotyping, the DQB1*0201/2 (p <0.00001) and DR3 (p <0.00001), DR7 (p <0.01) alleles showed significant positive association with the disease.

Original languageEnglish
Pages (from-to)122-129
Number of pages8
JournalScandinavian Journal of Gastroenterology, Supplement
Volume33
Issue number228
Publication statusPublished - 1998

Fingerprint

Celiac Disease
Glutathione Disulfide
Abdomen
Hair
Gluten-Free Diet
Reference Values
Erythrocytes
Diet
Glutathione
Hyperprolactinemia
Acute Abdomen
Glutens
Acute Disease
Prolactin
Electron Scanning Microscopy
Meals
Protons
Zinc
Iron
Alleles

Keywords

  • Children
  • Coeliac
  • Genetics
  • Hair characteristics
  • Oxidant stress
  • Prolactin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Coeliac disease : Always something to discover. / Várkonyi, A.; Boda, M.; Endreffy, E.; Németh, I.; Timár, E.

In: Scandinavian Journal of Gastroenterology, Supplement, Vol. 33, No. 228, 1998, p. 122-129.

Research output: Contribution to journalArticle

@article{3ff29a84d8944212b35f55e9494ba442,
title = "Coeliac disease: Always something to discover",
abstract = "The authors present more than 20 years' experience with coeliac disease, with a summary of their published studies. Hair shaft characteristics were determined by scanning electron microscopy. Hair diameter was significantly lower and cuticular erosion scores higher in those who were not on gluten- free diets as compared to controls, showing a tendency towards normal values following start of gluten-free diets. Proton-induced X-ray emission showed significantly lower zinc content of the hair shaft in the group with acute coeliac disease and after a short-term diet, which approached the normal range only after a yearlong diet. The serum prolactin levels in healthy controls and in coeliac patients on the diet were within normal limits, whereas in children with coeliac disease taking gluten in their meals, a significant hyperprolactinaemia was found. The erythrocyte glutathione content of coeliac children was elevated, and the glutathione disulfide level was significantly decreased, as compared to values in normal controls. The erythrocyte glutathione disulfide level and glutathione disulfide/erythrocyte glutathione ratio in coeliac children also differed from those in children with iron deficiency. With genotyping, the DQB1*0201/2 (p <0.00001) and DR3 (p <0.00001), DR7 (p <0.01) alleles showed significant positive association with the disease.",
keywords = "Children, Coeliac, Genetics, Hair characteristics, Oxidant stress, Prolactin",
author = "A. V{\'a}rkonyi and M. Boda and E. Endreffy and I. N{\'e}meth and E. Tim{\'a}r",
year = "1998",
language = "English",
volume = "33",
pages = "122--129",
journal = "Scandinavian Journal of Gastroenterology, Supplement",
issn = "0085-5928",
publisher = "Taylor and Francis Ltd.",
number = "228",

}

TY - JOUR

T1 - Coeliac disease

T2 - Always something to discover

AU - Várkonyi, A.

AU - Boda, M.

AU - Endreffy, E.

AU - Németh, I.

AU - Timár, E.

PY - 1998

Y1 - 1998

N2 - The authors present more than 20 years' experience with coeliac disease, with a summary of their published studies. Hair shaft characteristics were determined by scanning electron microscopy. Hair diameter was significantly lower and cuticular erosion scores higher in those who were not on gluten- free diets as compared to controls, showing a tendency towards normal values following start of gluten-free diets. Proton-induced X-ray emission showed significantly lower zinc content of the hair shaft in the group with acute coeliac disease and after a short-term diet, which approached the normal range only after a yearlong diet. The serum prolactin levels in healthy controls and in coeliac patients on the diet were within normal limits, whereas in children with coeliac disease taking gluten in their meals, a significant hyperprolactinaemia was found. The erythrocyte glutathione content of coeliac children was elevated, and the glutathione disulfide level was significantly decreased, as compared to values in normal controls. The erythrocyte glutathione disulfide level and glutathione disulfide/erythrocyte glutathione ratio in coeliac children also differed from those in children with iron deficiency. With genotyping, the DQB1*0201/2 (p <0.00001) and DR3 (p <0.00001), DR7 (p <0.01) alleles showed significant positive association with the disease.

AB - The authors present more than 20 years' experience with coeliac disease, with a summary of their published studies. Hair shaft characteristics were determined by scanning electron microscopy. Hair diameter was significantly lower and cuticular erosion scores higher in those who were not on gluten- free diets as compared to controls, showing a tendency towards normal values following start of gluten-free diets. Proton-induced X-ray emission showed significantly lower zinc content of the hair shaft in the group with acute coeliac disease and after a short-term diet, which approached the normal range only after a yearlong diet. The serum prolactin levels in healthy controls and in coeliac patients on the diet were within normal limits, whereas in children with coeliac disease taking gluten in their meals, a significant hyperprolactinaemia was found. The erythrocyte glutathione content of coeliac children was elevated, and the glutathione disulfide level was significantly decreased, as compared to values in normal controls. The erythrocyte glutathione disulfide level and glutathione disulfide/erythrocyte glutathione ratio in coeliac children also differed from those in children with iron deficiency. With genotyping, the DQB1*0201/2 (p <0.00001) and DR3 (p <0.00001), DR7 (p <0.01) alleles showed significant positive association with the disease.

KW - Children

KW - Coeliac

KW - Genetics

KW - Hair characteristics

KW - Oxidant stress

KW - Prolactin

UR - http://www.scopus.com/inward/record.url?scp=0032252972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032252972&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 122

EP - 129

JO - Scandinavian Journal of Gastroenterology, Supplement

JF - Scandinavian Journal of Gastroenterology, Supplement

SN - 0085-5928

IS - 228

ER -