Coding in the noncoding DNA strand: A novel mechanism of gene evolution?

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The question whether the noncoding DNA strand had or still has the capability for encoding functional polypeptides has been addressed in several articles. The theoretical background of the views advocating this idea arose from two groups of findings. One of them was based on various observations implying that the genetic code was adapted for double-strand coding. The other group of theories arose from the observation of gene-length overlapping open reading frames (O-ORFs) on the antisense DNA strand in a number of genes. In fact, the above theories, which I term selectionist, conceive a novel conception of gene evolution, proposing that new genes can be created by the utilization of antisense DNA strand. In contrast, neutralist theory claims that the O-ORFs are mere by-products of evolutionary processes acting to create special codon usage and base distribution patterns in the coding sequences.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalJournal of Molecular Evolution
Volume51
Issue number6
Publication statusPublished - 2000

Fingerprint

Antisense DNA
intergenic DNA
antisense DNA
Genes
DNA
Open Reading Frames
gene
Overlapping Genes
Genetic Code
open reading frames
genes
Codon
genetic code
Observation
codons
byproducts
Byproducts
polypeptides
Peptides

Keywords

  • Antisense DNA strand
  • Codon usage
  • G + C content
  • Gene evolution
  • Genetic Code
  • Overlapping ORF

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Coding in the noncoding DNA strand : A novel mechanism of gene evolution? / Boldogkői, Z.

In: Journal of Molecular Evolution, Vol. 51, No. 6, 2000, p. 600-606.

Research output: Contribution to journalArticle

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