Abstract
The question whether the noncoding DNA strand had or still has the capability for encoding functional polypeptides has been addressed in several articles. The theoretical background of the views advocating this idea arose from two groups of findings. One of them was based on various observations implying that the genetic code was adapted for double-strand coding. The other group of theories arose from the observation of gene-length overlapping open reading frames (O-ORFs) on the antisense DNA strand in a number of genes. In fact, the above theories, which I term selectionist, conceive a novel conception of gene evolution, proposing that new genes can be created by the utilization of antisense DNA strand. In contrast, neutralist theory claims that the O-ORFs are mere by-products of evolutionary processes acting to create special codon usage and base distribution patterns in the coding sequences.
| Original language | English |
|---|---|
| Pages (from-to) | 600-606 |
| Number of pages | 7 |
| Journal | Journal of Molecular Evolution |
| Volume | 51 |
| Issue number | 6 |
| Publication status | Published - 2000 |
Fingerprint
Keywords
- Antisense DNA strand
- Codon usage
- G + C content
- Gene evolution
- Genetic Code
- Overlapping ORF
ASJC Scopus subject areas
- Genetics
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics(clinical)
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
Cite this
Coding in the noncoding DNA strand : A novel mechanism of gene evolution? / Boldogkői, Z.
In: Journal of Molecular Evolution, Vol. 51, No. 6, 2000, p. 600-606.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coding in the noncoding DNA strand
T2 - A novel mechanism of gene evolution?
AU - Boldogkői, Z.
PY - 2000
Y1 - 2000
N2 - The question whether the noncoding DNA strand had or still has the capability for encoding functional polypeptides has been addressed in several articles. The theoretical background of the views advocating this idea arose from two groups of findings. One of them was based on various observations implying that the genetic code was adapted for double-strand coding. The other group of theories arose from the observation of gene-length overlapping open reading frames (O-ORFs) on the antisense DNA strand in a number of genes. In fact, the above theories, which I term selectionist, conceive a novel conception of gene evolution, proposing that new genes can be created by the utilization of antisense DNA strand. In contrast, neutralist theory claims that the O-ORFs are mere by-products of evolutionary processes acting to create special codon usage and base distribution patterns in the coding sequences.
AB - The question whether the noncoding DNA strand had or still has the capability for encoding functional polypeptides has been addressed in several articles. The theoretical background of the views advocating this idea arose from two groups of findings. One of them was based on various observations implying that the genetic code was adapted for double-strand coding. The other group of theories arose from the observation of gene-length overlapping open reading frames (O-ORFs) on the antisense DNA strand in a number of genes. In fact, the above theories, which I term selectionist, conceive a novel conception of gene evolution, proposing that new genes can be created by the utilization of antisense DNA strand. In contrast, neutralist theory claims that the O-ORFs are mere by-products of evolutionary processes acting to create special codon usage and base distribution patterns in the coding sequences.
KW - Antisense DNA strand
KW - Codon usage
KW - G + C content
KW - Gene evolution
KW - Genetic Code
KW - Overlapping ORF
UR - http://www.scopus.com/inward/record.url?scp=0034542622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034542622&partnerID=8YFLogxK
M3 - Article
C2 - 11116333
AN - SCOPUS:0034542622
VL - 51
SP - 600
EP - 606
JO - Journal of Molecular Evolution
JF - Journal of Molecular Evolution
SN - 0022-2844
IS - 6
ER -