Coating polymer-plasticizer interaction in relation to the enthalpy relaxation of polymer

R. Zelkó, Á Orbán, J. Nagy, G. Csóka, I. Rácz

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13 Citations (Scopus)

Abstract

In the course of the formulation of coated dosage forms, the selection of the suitable composition of the coating system is of great importance in respect of the final dosage form. Since the applied coating systems are multicomponent, the possible interactions between the components determine the physico-chemical stability of the formulated dosage form, the drug release process, as well as the formulation parameters. In the present study, the influence of the applied plasticizer, dibutyl sebacate on the enthalpy relaxation of casted Eudragit L 30D films was determined as a function of the plasticizer concentration. The enthalpy relaxation was recorded by DSC during the applied isothermal recovery process of Eudragit films. The obtained results indicate that enthalpy relaxation can be measured by DSC at 20 mass/mass% dibutyl sebacate concentration, which refers to the increased molecular mobility consequently to the effect of the interaction between the polymer and plasticizer.

Original languageEnglish
Pages (from-to)531-537
Number of pages7
JournalJournal of Thermal Analysis and Calorimetry
Volume68
Issue number2
DOIs
Publication statusPublished - Jun 20 2002

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Keywords

  • Dibutyl sebacate
  • Enthalpy relaxation
  • Eudragit L 30D
  • Interaction

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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