Coating of intravascular balloon with paclitaxel prevents constrictive remodeling of the dilated porcine femoral artery due to inhibition of intimal and media fibrosis

Noemi Pavo, Eslam Samaha, Inna Sabdyusheva, Rembert Pogge von Strandmann, Stefanie Stahnke, Christian A. Plass, Katrin Zlabinger, Dominika Lukovic, Zoltan Jambrik, Imre J. Pavo, Jutta Bergler-Klein, William A. Gray, Gerald Maurer, Mariann Gyöngyösi

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Abstract

Here we investigated how a coating of intravascular balloon with paclitaxel (drug-coated balloon; DCB, Freeway™) impacted porcine peripheral artery vascular function and remodeling. Domestic swine (n = 54) underwent percutaneous overstretch balloon dilation of femoral and iliac arteries, controlled by angiography and optical coherence tomography (OCT). Paclitaxel tissue uptake was measured at 1 h and 1, 3, and 9 days post-dilation. At these time-points and at 32 ± 2 days, vascular function of the dilated arteries was assessed using the organ chamber model. Neointimal growth and remodeling indices were determined using OCT and histology at 32 ± 2 days. Intima and media fibrosis were quantified by picrosirius red staining. Post-inflation femoral artery tissue drug levels were 460 ± 214, 136 ± 123, 14 ± 6, and 0.1 ± 0.1 ng/mg at 1 h and 1, 3, and 9 days, respectively. Compared to plain balloon, Freeway™ resulted in a significantly smaller neointimal area (P < 0.05), less tunica intima (8.0 ± 5.4 vs 14.2 ± 4.7 %) and media fibrosis (15.6 ± 7.7 vs 24.5 ± 5.4 %), and less femoral artery constrictive remodeling (remodeling index: 1.08 ± 0.08 vs 0.94 ± 0.08). The DCB was associated with significantly increased vasoconstrictor tone and endothelium-dependent vasodilation impairment shortly after post-overstretch injury. Overall, DCB dilation of peripheral arteries resulted in high drug uptake into arterial tissue. Compared with the plain balloon, the DCB was associated with decreased vessel wall fibrosis after balloon overstretch injury, and reduced degrees of constrictive remodeling and neointimal hyperplasia.

Original languageEnglish
Article number131
JournalJournal of Materials Science: Materials in Medicine
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

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ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Pavo, N., Samaha, E., Sabdyusheva, I., von Strandmann, R. P., Stahnke, S., Plass, C. A., Zlabinger, K., Lukovic, D., Jambrik, Z., Pavo, I. J., Bergler-Klein, J., Gray, W. A., Maurer, G., & Gyöngyösi, M. (2016). Coating of intravascular balloon with paclitaxel prevents constrictive remodeling of the dilated porcine femoral artery due to inhibition of intimal and media fibrosis. Journal of Materials Science: Materials in Medicine, 27(8), [131]. https://doi.org/10.1007/s10856-016-5737-y