Coagulation factor deficiencies and pregnancy loss

Aida Inbal, L. Muszbek

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Of all the coagulation factor deficiencies, only deficiency of factor XIII (FXIII) and fibrinogen are associated with pregnancy loss. FXIII deficiency and a complete or partial deficiency of fibrinogen are associated with bleeding since childhood, impaired wound repair, and recurrent spontaneous abortions. Both FXIII and fibrinogen play an essential role in placental implantation and maintenance of pregnancy. The causes of miscarriages in FXIII or fibrinogen-deficient women is discussed and an appropriate treatment advocated.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalSeminars in Thrombosis and Hemostasis
Volume29
Issue number2
DOIs
Publication statusPublished - Apr 2003

Fingerprint

Blood Coagulation Factors
Factor XIII Deficiency
Fibrinogen
Factor XIII
Spontaneous Abortion
Pregnancy
Afibrinogenemia
Pregnancy Maintenance
Habitual Abortion
Hemorrhage
Wounds and Injuries
Therapeutics

Keywords

  • Afibrinogenemia
  • Factor XIII deficiency
  • Miscarriages

ASJC Scopus subject areas

  • Hematology

Cite this

Coagulation factor deficiencies and pregnancy loss. / Inbal, Aida; Muszbek, L.

In: Seminars in Thrombosis and Hemostasis, Vol. 29, No. 2, 04.2003, p. 171-174.

Research output: Contribution to journalArticle

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