Coagulation factor deficiencies and pregnancy loss

Aida Inbal, Laszlo Muszbek

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

Of all the coagulation factor deficiencies, only deficiency of factor XIII (FXIII) and fibrinogen are associated with pregnancy loss. FXIII deficiency and a complete or partial deficiency of fibrinogen are associated with bleeding since childhood, impaired wound repair, and recurrent spontaneous abortions. Both FXIII and fibrinogen play an essential role in placental implantation and maintenance of pregnancy. The causes of miscarriages in FXIII or fibrinogen-deficient women is discussed and an appropriate treatment advocated.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalSeminars in Thrombosis and Hemostasis
Volume29
Issue number2
DOIs
Publication statusPublished - Apr 1 2003

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Keywords

  • Afibrinogenemia
  • Factor XIII deficiency
  • Miscarriages

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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